2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  4. ROR

ROR

RAR-related orphan receptor

ROR

Related Products

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Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and belonging to the orphan nuclear receptor family. The ROR subfamily contains three members: RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) and function as ligand-dependent transcription factors.

RORs are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis.

RORα and RORγ are important regulators of the immune system. The development and differentiation of Th17 cells are dependent on these factors. RORγ is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and γδ T cells, which contribute to inflammation and autoimmune disease.

ROR Isoform Specific Products:

ROR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169952
    RORγt inverse agonist 33
    		Inhibitor
    RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable and inverse agonists of RORγt, with the IC50 of 21 nM. RORγt inverse agonist 33 plays an important role in rheumatoid arthritis research.
    RORγt inverse agonist 33
  • HY-170995
    PROTAC ROR1 degrader-1
    		Degrader
    PROTAC ROR1 degrader-1 is a ROR1 PROTAC degrader with DC50 values of 40.88 nM (NCI-H23), 69.0 nM (NCI-H460), 83.35 nM (NCI-H1299) and 42.07 nM (NCI-H1975), respectively. PROTAC ROR1 degrader-1 inhibits the proliferation of lung cancer cells and induces apoptosis. PROTAC ROR1 degrader-1 can be used in research related to non-small cell lung cancer.
    PROTAC ROR1 degrader-1
  • HY-RS12129
    RORB Human Pre-designed siRNA Set A
    		Inhibitor

    RORB Human Pre-designed siRNA Set A contains three designed siRNAs for RORB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    RORB Human Pre-designed siRNA Set A
  • HY-163611
    XY039
    		Agonist
    XY039 (compound 13e) is a RORγ inverse agonist with the IC50 of 0.55 μM. XY039 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro.
    XY039
  • HY-155548
    RORγt inverse agonist 31
    		Inhibitor
    RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice.
    RORγt inverse agonist 31
  • HY-143712S1
    Allolithocholic Acid-d4
    		Inhibitor
    Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
    Allolithocholic Acid-d<sub>4</sub>
  • HY-175361
    RORγ agonist 2
    		Agonist
    RORγ agonist 2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03  μM for hRORγ. RORγ agonist 2 significantly inhibits tumors growth in syngeneic MC38 tumor mice model.
    RORγ agonist 2
  • HY-170996
    ROR1 ligand-1
    		Degrader
    ROR1 ligand-1 is a ROR1 ligand that can be used for synthesis of PROTACT ROR1 degrader-1 (HY-170995).
    ROR1 ligand-1
  • HY-180813
    RORγ-IN-3
    		Inhibitor
    RORγ-IN-3 (Compound 21) is a potent and highly selective RORγ inhibitor with an EC50 of 84 nM. RORγ-IN-3 can effectively inhibit the production of IL-17, with an IC₅₀ value of 1.0 μM. RORγ-IN-3 can be used for the study of autoimmune diseases.
    RORγ-IN-3
  • HY-170370
    RORγt inverse agonist 34
    		Inhibitor
    RORγt inverse agonist 34 (compound 5a) is a RORγt inverse agonist with an IC50 of 0.094 μM for RORγt-LBD. RORγt inverse agonist 34 is used for psoriasis research.
    RORγt inverse agonist 34
  • HY-160021
    RORγt agonist 4
    		Agonist
    RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma.
    RORγt agonist 4
  • HY-183763
    RORγt inverse agonist 37
    		Agonist
    RORγt inverse agonist 37 is an orally active RORγt inverse agonist with an IC50 of 10.8 nM against human targets. RORγt inverse agonist 37 destabilizes helix 12 of RORγt in the agonist-bound conformation, thereby inhibiting transcriptional activity. RORγt inverse agonist 37 inhibits the secretion of IL-17 in cells and in LPS-induced systemic inflammation mouse models. RORγt inverse agonist 37 improves disease-related symptoms in mouse models of psoriasiform dermatitis. RORγt inverse agonist 37 can be used in research related to psoriasiform dermatitis and systemic inflammation.
    RORγt inverse agonist 37
  • HY-174382
    ROR1-IN-3
    		Inhibitor
    ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC50 = 17.6 nM). ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-κB signaling pathway. ROR1-IN-3 can be studied in antitumor research.
    ROR1-IN-3
  • HY-168179
    RORγt inverse agonist 32
    		Inhibitor
    RORγt inverse agonist 32 (compound b14) is orally active. RORγt inverse agonist 32 can be used in inflammation research.
    RORγt inverse agonist 32
  • HY-182716
    BMS-336
    		Inhibitor
    BMS-336 (Compound 89) is a RORγ inhibitor. BMS-336 can be used for the research of cancer.
    BMS-336
  • HY-143271
    RORγt inverse agonist 29
    		Inhibitor
    RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC50: 21 nM). RORγt inverse agonist 29 can be used in the research of skin inflammation and autoimmune diseases like psoriasis.
    RORγt inverse agonist 29
  • HY-142934
    RORγt inhibitor 2
    		Inhibitor
    RORγt inhibitor 2 (Compound 119) is a potent RORγt inhibitor with an IC50 of 9.2 nM. RORγt inhibitor 2 can be used for the research of cancer, inflammation or autoimmune diseases mediated by RORγt.
    RORγt inhibitor 2
  • HY-179514
    Gala-SR
    		Agonist
    Gala-SR (Gala-SR1078) is an RORα agonist. Gala-SR ameliorates rhythm disorders by enhancing the amplitude of the circadian rhythm. Gala-SR can be used for the study of periodontitis.
    Gala-SR
  • HY-111366
    CD12681
    		Agonist
    CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis.
    CD12681
  • HY-RS12130
    Rorb Mouse Pre-designed siRNA Set A
    		Inhibitor

    Rorb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rorb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Rorb Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
ROR Isoform Comparison

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