2. シグナル伝達
  3. Anti-infection
  4. Antibiotic
  5. Macrolide Isoform

Macrolide

Macrolides are a class of antibiotics that exert their core biological function by inhibiting bacterial protein synthesis through interaction with the bacterial ribosome, thereby suppressing microbial growth[1][2]. Mechanistically, macrolides bind within the nascent peptide exit tunnel of the 50S ribosomal subunit and interfere with translation by preventing normal elongation of the growing peptide chain during protein biosynthesis[1][2][3]. This translational inhibition pathway is closely linked to interactions with 23S rRNA and ribosomal components that regulate peptide progression through the ribosome[2][3][4]. In disease settings, macrolides are widely used for bacterial infections and have also demonstrated anti-inflammatory and immunomodulatory activities that contribute to their application in chronic respiratory disorders, including chronic obstructive pulmonary disease and non-cystic fibrosis bronchiectasis[4][5]. Compared with other ribosome-targeting antibiotic classes, macrolides are distinguished by their binding site within the 50S subunit and their ability to selectively affect protein synthesis through obstruction of the peptide exit tunnel[2][3]. Research on related compounds has further shown that structural modification of the macrolide scaffold can generate derivatives with activity against macrolide-resistant bacteria, providing useful experimental tools for investigating resistance mechanisms and ribosome function[5][6]. Therefore, macrolides remain important molecular probes for studying translation regulation, antibiotic resistance, and host inflammatory responses in infection-related experimental models[1][4][6].

Macrolide 関連製品 (74):

製品番号 製品名 製品効果 純度
  • HY-N6738
    Bafilomycin B1 98.10%
    Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets.
  • HY-100584
    Davercin 98.0%
    Davercin (Erythromycin Cyclocarbonate), derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.
  • HY-B0519B
    Tylosin phosphate 99.27%
    Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.
  • HY-B0220S1
    Erythromycin-13C,d3 99.50%
    Erythromycin-13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.
  • HY-126906
    Milbemycin A4 99.13%
    Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activitysup>[2].
  • HY-B0220S2
    Erythromycin-d3
    Erythromycin-d3 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research.
  • HY-126479
    Carbomycin B
    Carbomycin B is a macrolide antibiotic.
  • HY-B0220R
    Erythromycin (Standard)
    Erythromycin (Standard) is the analytical standard of Erythromycin. This product is intended for research and analytical applications. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research.
  • HY-N6783
    Oligomycin C 99.26%
    Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria.
  • HY-B0519AS
    Tylosin-d3
    Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.
  • HY-13756S2
    Tacrolimus-d3
    Tacrolimus-d3 (FK506-d3) is the deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
  • HY-B0220C
    Erythromycin (aspartate)
    Erythromycin aspartate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin aspartate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin aspartate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
  • HY-112661
    PC-766B
    PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na+, K+-ATPase.
  • HY-N8386
    Berkeleylactone F
    Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells.
  • HY-B1920A
    Josamycin hydrochloride
    Josamycin (EN-141) hydrochloride is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin hydrochloride is 5.5 nM.
  • HY-121182
    Chalcomycin
    Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD50 >2500 mg/kg).
  • HY-125707
    Concanamycin B
    Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM.
  • HY-N13154
    Malolactomycin C
    Malolactomycin C (compound 1) is a macrolide antifungal antibiotic isolated from Streptomyces strain KP-3144. Malolactomycin C is an effective inhibitor of Botrytis cinerea and thus controls a variety of plant diseases including gray mold.
  • HY-124138
    Pikromycin
    Pikromycin is a macrolide antibiotic that has been found in S. venezuelae and active against E. coli, S. aureus and B. subtilis.
  • HY-121000
    Albocycline
    Albocycline (Ingramycin) is a macrolide antibiotic, which exhibits antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin (HY-B0671)-intermediate (VISA), and Vancomycin (HY-B0671)-resistant S. aureus (VRSA) strains with MICs ranging from 0.5 to 1.0 μg/mL. Albocycline exhibits no toxicity to human cells at concentration of ≤64 μg/mL.