Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
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Beta-lactamase Related Products (253)
Related Products (253)
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Beta-lactamase Isoform Comparison
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ent-Avibactam sodium
0 ImagesCat. No.: HY-14879DCAS No.: 396731-20-7Synonyms: AVE1330AEnt-Avibactam sodium (AVE1330A) is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), ent-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of ent-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes.
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(2R,4R,6S)-Tubacin
0 ImagesCat. No.: HY-110061CAS No.: 1350555-93-9
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NDM-1 inhibitor-7
0 ImagesCat. No.: HY-170835CAS No.: 26151-73-5NDM-1 inhibitor-7 (Compound A8) is a NDM-1 inhibitor, with IC50 of 10.284 μM. NDM-1 inhibitor-7 restores the ability of MEM to penetrate the cell wall of gram-negative bacteria. NDM-1 inhibitor-7 effectively restores the antibacterial activity of MEM against NDM-1-positive Escherichia coli. NDM-1 inhibitor-7 demonstrates strong efficacy in both the Galleria mellonella infection model and murine peritonitis infection model.
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Nitrocefin (Standard)
0 ImagesCat. No.: HY-108913RCAS No.: 41906-86-9Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics.
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D-CS319
0 ImagesCat. No.: HY-175489CAS No.: 1770826-25-9D-CS319 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 2.0 and 3.0 μM for IMP-1 and IMP-78, respectively. D-CS319 has antibacterial activity.
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Metallo-β-lactamase-IN-12
0 ImagesCat. No.: HY-161094CAS No.: 3028594-43-3Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity.
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Cefuroxime sodium (Standard)
0 ImagesCefuroxime (sodium) (Standard) is the analytical standard of Cefuroxime (sodium). This product is intended for research and analytical applications. Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria.
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Nafcillin sodium monohydrate (Standard)
0 ImagesCat. No.: HY-B0555ARCAS No.: 7177-50-6Nafcillin (sodium monohydrate) (Standard) is the analytical standard of Nafcillin (sodium monohydrate). This product is intended for research and analytical applications. Nafcillin sodium monohydrate, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium monohydrate can be used for the research of staphylococcal infections.
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Enmetazobactam (Standard)
0 ImagesCat. No.: HY-103095RCAS No.: 1001404-83-6Synonyms: AAI101 (Standard)Enmetazobactam (Standard) is the analytical standard of Enmetazobactam (HY-103095). This product is intended for research and analytical applications. Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.
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3-Cyanochromone
0 ImagesCat. No.: HY-122711CAS No.: 50743-17-43-Cyanochromone (Compound fragment 1) is a dual NDM-1 and VIM-2 inhibitor with KD values of 181 μM and 999 μM, respectively. 3-Cyanochromone is promising for research of antibiotics.
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7-Aminocephalosporanic acid (Standard)
0 Images7-Aminocephalosporanic acid (Standard) is the analytical standard of 7-Aminocephalosporanic acid. This product is intended for research and analytical applications. 7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.
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NDM-1-IN-10
0 ImagesCat. No.: HY-178019CAS No.: 3044733-61-8NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 36 nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli ( MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1). NDM-1-IN-10 can be used for bacterial infections research.
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Tigemonam
0 ImagesCat. No.: HY-U00380CAS No.: 102507-71-1Tigemonam is an orally active monobactam antibiotic with a Ki of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection.
