2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1923A
    Piperacillin hydrate
    		Inhibitor
    Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418).
    Piperacillin hydrate
  • HY-144261
    Metallo-β-lactamase-IN-3
    		Inhibitor
    Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7.
    Metallo-β-lactamase-IN-3
  • HY-B1256AR
    Cefuroxime (Standard)
    		Inhibitor
    Cefuroxime (Standard) is the analytical standard of Cefuroxime. This product is intended for research and analytical applications. Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria.
    Cefuroxime (Standard)
  • HY-14879BR
    Avibactam sodium hydrate (Standard)
    		Inhibitor
    Avibactam (sodium hydrate) (Standard) is the analytical standard of Avibactam (sodium hydrate). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
    Avibactam sodium hydrate (Standard)
  • HY-161310
    Metallo-β-lactamase-IN-15
    		Inhibitor
    Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively.
    Metallo-β-lactamase-IN-15
  • HY-155104
    MBL-IN-1
    		Inhibitor
    MBL-IN-1 (compound 41) is a β-Lactamase inhibitor, with the IC50 ranging from 0.10 to 25.85 µM. MBL-IN-1 can be used for research of bacterial infections.
    MBL-IN-1
  • HY-155202
    YJ196
    		Inhibitor
    YJ196 (Compound 59) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor.
    YJ196
  • HY-160255A
    N-Cbz-D-Cysteine
    		Inhibitor
    N-Cbz-D-Cysteine (Cbz-D-Cys) (compound 5) is a potent β-lactamase II inhibitor with a Ki value of 20.1 µM.
    N-Cbz-D-Cysteine
  • HY-N2359S
    Chelerythrine-d6 chloride
    Chelerythrine-d6 is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy.
    Chelerythrine-d<sub>6</sub> chloride
  • HY-14879E
    rel-Avibactam sodium
    		Inhibitor
    Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime (HY-B0593), rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes.
    rel-Avibactam sodium
  • HY-P11720
    M104 peptide
    		Inhibitor
    M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48. M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection.
    M104 peptide
  • HY-A0256R
    Clavulanic acid (Standard)
    		Inhibitor
    Clavulanic acid (Standard) is the analytical standard of Clavulanic acid. This product is intended for research and analytical applications. Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias[1].
    Clavulanic acid (Standard)
  • HY-160255
    N-Cbz-L-Cysteine
    		Inhibitor
    N-Cbz-L-Cysteine (Cbz-cysteine) (compound 5) is a potent β-lactamase II inhibitor with a Ki value of 97 µM.
    N-Cbz-L-Cysteine
  • HY-144659
    Metallo-β-lactamase-IN-5
    		Inhibitor
    Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity.
    Metallo-β-lactamase-IN-5
  • HY-146165
    Metallo-β-lactamase-IN-8
    		Inhibitor
    Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity.
    Metallo-β-lactamase-IN-8
  • HY-182058
    ATM potentiator-1
    		Inhibitor
    ATM potentiators-1 is a quercetin derivative that synergistically enhances the antibacterial activity of Aztreonam (ATM, HY-B0129) against metallo-β-lactamase-producing Pseudomonas aeruginosa. ATM potentiators-1 inhibits NDM-1, OXA-10, VIM-2, KPC-2, and OXA-48, suppressing the efflux pump activity of Pseudomonas aeruginosa. When used in combination with CCCP (HY-100941), it exhibits a synergistic inhibitory effect. ATM potentiators-1 is applicable to research related to Pseudomonas aeruginosa infections.
    ATM potentiator-1
  • HY-P2998A
    β-Lactamase, Pseudomonas aeruginosa
    β-Lactamase, Pseudomonas aeruginosa (EC 3.5.2.6) inactivates β-lactam antibiotics by breaking open the β-lactam ring.
    β-Lactamase, Pseudomonas aeruginosa
  • HY-139744
    FPI-1465
    		Inhibitor
    FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively.
    FPI-1465
  • HY-19050
    BRL-42715
    		Inhibitor
    BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .
    BRL-42715
  • HY-B1825R
    Cefoxitin (Standard)
    Cefoxitin (Standard) is the analytical standard of Cefoxitin. This product is intended for research and analytical applications. Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
    Cefoxitin (Standard)
Beta-lactamase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.