2. Anti-infection
  3. Beta-lactamase Bacterial
  4. M104 peptide

M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48. M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection.

For research use only. We do not sell to patients.

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M104 peptide

M104 peptide Chemical Structure

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M104 peptide Related Antibodies

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Description

M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48. M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection[1][2].

In Vitro

M104 peptide (7-125 μg/mL; 18 h) reduces the meropenem MIC by 4-fold against a meropenem-resistant, blaOXA-48-harboring Klebsiella pneumoniae strain, restoring intermediate susceptibility to meropenem[1].
Peptide M104 (50-200 μg/mL; 18 h) enhances meropenem's biofilm inhibition activity against strong biofilm-forming blaOXA-48-positive Klebsiella pneumoniae clinical isolates, reducing meropenem MBIC values by two-fold for all 5 tested isolates, though the overall effect is not statistically significant (p-value = 0.06)[2].
Peptide M104 (200 μg/mL; 24-48 h) is non-cytotoxic to HDFa cells after 24 h of incubation, but causes a significant 9.9% reduction in cell viability after 48 h of incubation[2].
Peptide M104 (200 μg/mL; 1 h) exhibits no hemolytic activity against fresh human red blood cells after 1 h of incubation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M104 peptide Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Human dermal fibroblast (HDFa) cell line
Concentration: 200 μg/mL
Incubation Time: 24 h; 48 h
Result: Maintained a mean cell viability of 99.6% in HDFa cells after 24 h of incubation, which was not statistically different from the untreated control (p-value > 0.05).
Reduced mean cell viability significantly to 90.1% after 48 h of incubation compared to the untreated control (p-value < 0.05).
Molecular Weight

2481.87

Formula

C117H173N29O29S
Sequence

Met-Glu-Ala-Phe-Ile-Val-Ser-Ala-Phe-Lys-His-Gln-Ala-Glu-Gly-Phe-Lys-Leu-His-Tyr-Lys
Sequence Shortening

MEAFIVSAFKHQAEGFKLHYK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M104 peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M104 peptideBeta-lactamaseBacterialβ-lactamasemeropenemOXA-48 carbapenemasecarbapenem-resistant klebsiella pneumoniae infectionHDFa cellcarbapenem-resistant Klebsiella pneumoniae clinical isolatesblaOXA-48-harboring Klebsiella pneumoniae strainKlebsiella pneumoniaebiofilmfresh human red blood cellsOXA-48-like carbapenemaseInhibitorinhibitorinhibit

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M104 peptide
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HY-P11720
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