2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3823):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137905
    Pomalidomide-amido-C5-PEG2-C6-chlorine
    		98.75%
    Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivant of Pomalidomide (HY-10984).
    Pomalidomide-amido-C5-PEG2-C6-chlorine
  • HY-126247B
    (R)-BI-2852
    (R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    (R)-BI-2852
  • HY-108315
    6-Aminochrysene
    		99.71%
    6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. 6-Aminochrysene is activated by CYP450 in rat liver.
    6-Aminochrysene
  • HY-153754
    Phosphatidylcholine transfer protein inhibitor-1
    		98.01%
    Phosphatidylcholine transfer protein inhibitor-1 is a derivative of phosphatidylcholine transfer protein (PC-TP) inhibitor. Phosphatidylcholine transfer protein inhibitor-1 can be used for the research of obesity, type 2 diabetes, non-alcoholic fatty liver disease.
    Phosphatidylcholine transfer protein inhibitor-1
  • HY-15385
    Imexon
    		98.12%
    Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.
    Imexon
  • HY-106587A
    Octoclothepin maleate salt
    		99.14%
    Octoclothepin (Clorotepine) maleate salt is a D2 dopamine receptor antagonist and 5-HT2 serotonin receptor antagonist , with Ki values of 0.67 nM, 0.57 nM, and 0.19 nM for the dopamine D2, 5-HT2A, and 5-HT2C receptors, respectively. Octoclothepin maleate salt also binds to adrenergic receptors, with Ki values of 0.66 nM, 0.56 nM, and 0.77 nM for α1a, α1b, and α1d, respectively. Octoclothepin maleate salt can be used in schizophrenia research.
    Octoclothepin maleate salt
  • HY-N0386
    Griffonilide
    		99.77%
    Griffonilide is a steroidal compound that can be isolated from the roots of Semiaquilegia adoxoides.
    Griffonilide
  • HY-P11428
    DBCO-cyclo(RGDfK)
    		99.19%
    DBCO-cyclo(RGDfK) is a clickable RGD peptide and DBCO derivative of cyclo(RGDfK) (HY-P0023).
    DBCO-cyclo(RGDfK)
  • HY-P11111
    QP5
    		98.37%
    QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds to hydroxyapatite and demineralized enamel surfaces, temporarily stabilizes amorphous calcium phosphate (ACP), and regulates the crystallization of hydroxyapatite. QP5 promotes remineralization of artificial enamel caries in vitro, and acts synergistically with fluoride to enhance enamel caries remineralization. QP5 can be used in studies related to enamel caries and early enamel caries.
    QP5
  • HY-121435
    K-8012
    		99.51%
    K-8012 is a Sulindac (HY-B0008) analog and RXRα antagonist with an IC50 of 9.2 µM. K-8012 inhibits the activation of AKT. K-8012 induces Apoptosis, redirecting the TNFα signaling pathway from survival to death. K-8012 exerts anticancer activity against lung cancer, prostate cancer, and breast cancer. K-8012 can be used in research related to lung cancer, prostate cancer, breast cancer, and hepatocellular carcinoma.
    K-8012
  • HY-W014352
    trans-4-Bromocinnamaldehyde
    		99.87%
    trans-4-Bromocinnamaldehyde (Compound 6d) is an (E)-α,β-unsaturated aldehyde and cinnamaldehyde derivative. trans-4-Bromocinnamaldehyde serves as a starting material for the synthesis of α-aryl substituted phosphinomycin analogs. trans-4-Bromocinnamaldehyde can be used in the research of tuberculosis.
    trans-4-Bromocinnamaldehyde
  • HY-W006454
    5,6-Dihydropyridin-2(1H)-one
    		99.99%
    5,6-Dihydropyridin-2(1H)-one (1,5,6-Trihydropyridin-2-one) is a Sesquiterpenoids product that can be isolated from the leaves of Alpinia intermedia.
    5,6-Dihydropyridin-2(1H)-one
  • HY-131516
    Tiopronin-cysteine disulfide
    Tiopronin-cysteine disulfide is a soluble disulfide metabolite/derivative of Tiopronin (HY-B0373) formed by reaction of Tiopronin with cystine. Tiopronin-cysteine disulfide reduces cystine crystal formation in cystinuria. Tiopronin-cysteine disulfide can be used for the research of cystinuria.
    Tiopronin-cysteine disulfide
  • HY-113836
    3-Hydroxyhexanoic acid
    3-Hydroxyhexanoic acid is an ester product.
    3-Hydroxyhexanoic acid
  • HY-W398166
    (Z)-Hexadec-9-enamide
    (Z)-Hexadec-9-enamide (Palmitoleamide) is an ester product.
    (Z)-Hexadec-9-enamide
  • HY-148586
    β-Estradiol 17-hemisuccinate
    		98.83%
    β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol (HY-B0141).
    β-Estradiol 17-hemisuccinate
  • HY-W101588
    6-Methylheptanoic acid
    		98.77%
    6-Methylheptanoic acid is an ester product.
    6-Methylheptanoic acid
  • HY-B0931
    Citiolone
    		99.44%
    Citiolone is a derivative of cysteine and has the potential for research in liver diseases.
    Citiolone
  • HY-W019715
    trans-4-(Trifluoromethyl)cinnamic acid
    		99.88%
    trans-4-(Trifluoromethyl)cinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Cinnamomum cassia Presl.
    trans-4-(Trifluoromethyl)cinnamic acid
  • HY-105946A
    Hidrosmin (mixture)
    Hidrosmin (mixture) is a mixture of 3,5-di-O-(hydroxyethyl)diosmin and 3'-mono-O-(hydroxyethyl)diosmin.
    Hidrosmin (mixture)