Pomalidomide-amido-C5-PEG2-C6-chlorine

Name: Pomalidomide-amido-C5-PEG2-C6-chlorine
Brand: MedChemExpress
SKU: HY-137905
Rating: 4.5 (0 reviews)

製品番号: HY-137905 純度: 98.75%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivant of Pomalidomide (HY-10984).

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Pomalidomide-amido-C5-PEG2-C6-chlorine 構造式

CAS 番号 : 1835705-69-5

容量	価格（税別）	在庫状況	数量
1 mg	$350	在庫あり	Estimated Time of Arrival: December 31
5 mg	$875	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1405	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2810	在庫あり	Estimated Time of Arrival: December 31
50 mg	$4500	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivant of Pomalidomide (HY-10984)^[1].

分子量

594.10

分子式

C₂₉H₄₀ClN₃O₈

CAS 番号

1835705-69-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCOCCOCCOCCCCCCCl)NC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (168.32 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6832 mL	8.4161 mL	16.8322 mL
5 mM	0.3366 mL	1.6832 mL	3.3664 mL
10 mM	0.1683 mL	0.8416 mL	1.6832 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.22 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.22 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.2 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.75%

Select Batch:

データシート (264 KB) SDS (252 KB)

COA (243 KB) HNMR (358 KB) RP-HPLC (240 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6832 mL	8.4161 mL	16.8322 mL	42.0805 mL
	5 mM	0.3366 mL	1.6832 mL	3.3664 mL	8.4161 mL
	10 mM	0.1683 mL	0.8416 mL	1.6832 mL	4.2080 mL
	15 mM	0.1122 mL	0.5611 mL	1.1221 mL	2.8054 mL
	20 mM	0.0842 mL	0.4208 mL	0.8416 mL	2.1040 mL
	25 mM	0.0673 mL	0.3366 mL	0.6733 mL	1.6832 mL
	30 mM	0.0561 mL	0.2805 mL	0.5611 mL	1.4027 mL
	40 mM	0.0421 mL	0.2104 mL	0.4208 mL	1.0520 mL
	50 mM	0.0337 mL	0.1683 mL	0.3366 mL	0.8416 mL
	60 mM	0.0281 mL	0.1403 mL	0.2805 mL	0.7013 mL
	80 mM	0.0210 mL	0.1052 mL	0.2104 mL	0.5260 mL
	100 mM	0.0168 mL	0.0842 mL	0.1683 mL	0.4208 mL