QP5 

QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds to hydroxyapatite and demineralized enamel surfaces, temporarily stabilizes amorphous calcium phosphate (ACP), and regulates the crystallization of hydroxyapatite. QP5 promotes remineralization of artificial enamel caries in vitro, and acts synergistically with fluoride to enhance enamel caries remineralization. QP5 can be used in studies related to enamel caries and early enamel caries^[1][2].

QP5 (25 μM) binds strongly and stably to demineralized human tooth enamel, with greater binding compared to sound enamel^[1].
QP5 (200 μM; 30 min, 2 h, 24 h) transiently stabilizes ACP and directs its transformation into HA crystals with a natural enamel-matching Ca²⁺/P ratio of 1.67; when combined with fluoride, it directs formation of elongated rod-like HA/FHA crystals^[1].
QP5 (25 μM; four times daily for 5 min each, over 12 days) alone promotes remineralization of artificial human enamel caries with effects similar to fluoride, and when combined with fluoride, it exerts a synergistic effect that significantly enhances surface microhardness recovery, reduces mineral loss and lesion depth, and increases mineral content compared to either treatment alone^[1].
QP5 (600 μM; 2 h) adsorbs on nucleated minerals in solution via its functional domains, stabilizes amorphous calcium phosphate, and inhibits spontaneous nucleation of crystalline HAP after 2 hours of incubation^[2].
QP5 (200 μM; 30 min pre-coating, 14 days treatment) promotes biomimetic remineralization of demineralized bovine enamel, achieving a surface microhardness recovery of 72.07%^[2].
QP5 (100 ns; 310 K) stably adsorbs to the HAP (001) surface via negatively charged C-tail domain residues (Glu19, Glu20, Asp22) through electrostatic interactions, then recruits Ca²⁺ from solution to promote enamel biomimetic remineralization during 100 ns molecular dynamics simulation at 310 K^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2660.91

C₁₁₅H₁₇₈N₃₄O₃₇S

1501983-51-2

Solid

White to off-white

Gln-Pro-Tyr-Gln-Pro-Val-Gln-Pro-His-Gln-Pro-Met-Gln-Pro-Gln-Thr-Lys-Arg-Glu-Glu-Val-Asp

QPYQPVQPHQPMQPQTKREEVD

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Ding L, et al. Remineralization of enamel caries by an amelogenin-derived peptide and fluoride in vitro. Regen Biomater. 2020;7(3):283-292.  [Content Brief]

  [2]. Hu D, et al. Unveiling the mechanism of an amelogenin-derived peptide in promoting enamel biomimetic remineralization. Int J Biol Macromol. 2023;253(Pt 7):127322.