Tiopronin-cysteine disulfide 

Tiopronin-cysteine disulfide is a soluble disulfide metabolite/derivative of Tiopronin (HY-B0373) formed by reaction of Tiopronin with cystine. Tiopronin-cysteine disulfide reduces cystine crystal formation in cystinuria. Tiopronin-cysteine disulfide can be used for the research of cystinuria^[1][2].

Tiopronin-cysteine disulfide (2-20 mM; 0-48 h) forms as a soluble complex via disulfide bond exchange between Tiopronin (or Tiopronin released from Tiopronin-NO after NO cleavage) and cystine in artificial, healthy human, and cystinuria patient urine, with complete conversion observed at tested concentrations and incubation times, and this complex drives enhanced cystine solubility in urine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

282.34

C₈H₁₄N₂O₅S₂

77591-18-5

Solid

White to off-white

N[C@H](C(O)=O)CSSC(C(NCC(O)=O)=O)C

Room temperature in continental US; may vary elsewhere.

• [1]. Lindell A, et al. Clinical course and cystine stone formation during tiopronin treatment. Urol Res. 1995;23(2):111-117.  [Content Brief]

  [2]. Kumar A, et al. Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections. ACS Appl Mater Interfaces. 2023;15(37):43332-43344.  [Content Brief]