Tiopronin-cysteine disulfide
Based on 1 Customer Validation
Tiopronin-cysteine disulfide is a soluble disulfide metabolite/derivative of Tiopronin (HY-B0373) formed by reaction of Tiopronin with cystine. Tiopronin-cysteine disulfide reduces cystine crystal formation in cystinuria. Tiopronin-cysteine disulfide can be used for the research of cystinuria.
For research use only. We do not sell to patients.
- Purity: 96.78%
- CAS No.: 77591-18-5
- Formula: C8H14N2O5S2
- Molecular Weight:282.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tiopronin-cysteine disulfide (2-20 mM; 0-48 h) forms as a soluble complex via disulfide bond exchange between Tiopronin (or Tiopronin released from Tiopronin-NO after NO cleavage) and cystine in artificial, healthy human, and cystinuria patient urine, with complete conversion observed at tested concentrations and incubation times, and this complex drives enhanced cystine solubility in urine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 77591-18-5
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Appearance Solid
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Molecular Weight 282.34
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Formula C8H14N2O5S2
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Color White to off-white
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SMILES
N[C@H](C(O)=O)CSSC(C(NCC(O)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Lindell A, et al. Clinical course and cystine stone formation during tiopronin treatment. Urol Res. 1995;23(2):111-117. [Content Brief]
[2]. Kumar A, et al. Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections. ACS Appl Mater Interfaces. 2023;15(37):43332-43344. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tiopronin-cysteine disulfide Related Classifications
HY-131516 Related Classifications
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