Omeprazole sulfone-d₃  (Synonyms: Omeprazole sulfone-d₃; Omeprazole sulphone-d₃)

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair^[1][2][3].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

364.43

C₁₇H₁₆D₃N₃O₄S

2749628-17-7

88546-55-8

CC(C(OC)=C(C)C=N1)=C1CS(C2=NC3=C([2H])C([2H])=C(OC)C([2H])=C3N2)(=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Daujat M, et al. Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor[J]. Biochemical and biophysical research communications, 1992, 188(2): 820-825.

  [3]. Ng KM, et al. Omeprazole promotes gastric epithelial cell migration. J Pharm Pharmacol. 2008;60(5):655-660.

  [4]. Sumer E, et al. Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide. Drug Chem Toxicol. Published online July 28, 2025.