2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3817):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7717
    (-)-N-methylcoclaurine
    (-)-N-methylcoclaurine ((-)-(1R)-N-methylcoclaurine) is a benzylisoquinoline alkaloid and melanogenesis inhibitor with an IC50 of 6.5 μM that can be found in the flower buds of Nelumbo nucifera. (-)-N-methylcoclaurine inhibits theophylline-stimulated melanogenesis in melanoma cells. (-)-N-methylcoclaurine can be used for the research of skin hyperpigmentation disorders.
    (-)-N-methylcoclaurine
  • HY-108278R
    Zolimidine (Standard)
    Zolimidine (Standard) is the analytical standard of Zolimidine (HY-108278). This product is intended for research and analytical applications. Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research.
    Zolimidine (Standard)
  • HY-W564704
    (p-Hydroxybenzyl)malonic acid
    (p-Hydroxybenzyl)malonic acid is a hydroxyphenyl derivative capable of inhibiting insulin-induced lipogenesis in rat adipocytes with an IC50 value of 3.8 μM.
    (p-Hydroxybenzyl)malonic acid
  • HY-79602S1
    p-Toluenesulfonamide-15N
    p-Toluenesulfonamide-15N is the 15N-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is an intermediate and plasticizer. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum.
    p-Toluenesulfonamide-<sup>15</sup>N
  • HY-W585819S
    3-Chloropropane-1,2-diol dipalmitate-13C3
    3-Chloropropane-1,2-diol dipalmitate-13C3 (3-MPCD dipalmitate-13C3) is 13C labeled 3-Chloropropane-1,2-diol dipalmitate (HY-W585819). 3-Chloropropane-1,2-diol dipalmitate (3-MPCD dipalmitate) is a fatty acid ester of 3-monochloropropane-1,2-diol (3-MCPD) and a foodborne contaminant.
    3-Chloropropane-1,2-diol dipalmitate-<sup>13</sup>C<sub>3</sub>
  • HY-133658
    Chloroiodoacetic acid
    Chloroiodoacetic acid exists in the water disinfected with chlorine/hypochlorite.
    Chloroiodoacetic acid
  • HY-W414915R
    Valsartan methyl ester (Standard)
    Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
    Valsartan methyl ester (Standard)
  • HY-125162
    N-Glycine globotriaosylsphingosine (d18:1)
    N-Glycine globotriaosylsphingosine (d18:1) is a glycosphingolipid.
    N-Glycine globotriaosylsphingosine (d18:1)
  • HY-N3311
    Mayumbine
    Mayumbine (19-Epiajmalicine) is a natural alkaloid.
    Mayumbine
  • HY-106538R
    Cadralazine (Standard)
    Cadralazine (Standard) is the analytical standard of Cadralazine. This product is intended for research and analytical applications. Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator.
    Cadralazine (Standard)
  • HY-U00153R
    Dixyrazine (Standard)
    Dixyrazine (Standard) is the analytical standard of Dixyrazine. This product is intended for research and analytical applications. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.
    Dixyrazine (Standard)
  • HY-N0772R
    Isomangiferin (Standard)
    Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
    Isomangiferin (Standard)
  • HY-W114420
    3-Methyl-L-tyrosine
    3-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk.
    3-Methyl-L-tyrosine
  • HY-W588203
    β-Nornicotyrine
    β-Nornicotyrine (3-(1H-Pyrrol-2-yl)pyridine) is an alkaloid that has been found in N. tabacum. β-Nornicotyrine can be used for research on neurological diseases.
    β-Nornicotyrine
  • HY-171720
    Ascr#12
    Ascr#12 (Asc-C6) is an ascaroside derivative that exhibits extremely low activity in inducing the dauer (dormant larval) stage. Ascr#12 enhances the reproductive capacity of the invasive pine wood nematode.
    Ascr#12
  • HY-121478
    Nifoxipam
    Nifoxipam is a nitrobenzodiazepine.
    Nifoxipam
  • HY-170730
    Tosyl-methamphetamine
    Tosyl-methamphetamine (TS-Methamphetamine) is an amphetamine.
    Tosyl-methamphetamine
  • HY-49864
    Promolate
    Promolate is an isobutyric acid derivative with potent antitussive activity.
    Promolate
  • HY-168811
    α-Pyrrolidino-2-phenylacetophenone hydrochloride
    α-Pyrrolidino-2-phenylacetophenone hydrochloride is a drug derivative.
    α-Pyrrolidino-2-phenylacetophenone hydrochloride
  • HY-168426
    N-Methyl Homarylamine hydrochloride
    N-methyl Homarylamine hydrochloride is a phenethylamine.
    N-Methyl Homarylamine hydrochloride