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  3. Drug Derivative
  4. (-)-N-methylcoclaurine

(-)-N-methylcoclaurine  (Synonyms: (–)-(1R)-N-methylcoclaurine)

Cat. No.: HY-N7717
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(-)-N-methylcoclaurine ((-)-(1R)-N-methylcoclaurine) is a benzylisoquinoline alkaloid and melanogenesis inhibitor with an IC50 of 6.5 μM that can be found in the flower buds of Nelumbo nucifera. (-)-N-methylcoclaurine inhibits theophylline-stimulated melanogenesis in melanoma cells. (-)-N-methylcoclaurine can be used for the research of skin hyperpigmentation disorders.

For research use only. We do not sell to patients.

(-)-N-methylcoclaurine

(-)-N-methylcoclaurine Chemical Structure

CAS No. : 5096-70-8

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Other Forms of (-)-N-methylcoclaurine:

(-)-N-methylcoclaurine Related Antibodies

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Description

(-)-N-methylcoclaurine ((-)-(1R)-N-methylcoclaurine) is a benzylisoquinoline alkaloid and melanogenesis inhibitor with an IC50 of 6.5 μM that can be found in the flower buds of Nelumbo nucifera. (-)-N-methylcoclaurine inhibits theophylline-stimulated melanogenesis in melanoma cells. (-)-N-methylcoclaurine can be used for the research of skin hyperpigmentation disorders[1].

In Vitro

(-)-N-methylcoclaurine (3-30 μM) inhibits theophylline-stimulated melanogenesis in murine B16 melanoma 4A5 cells with an IC50 of 6.5 μM, without notable cytotoxicity at effective concentrations[1].
(-)-N-methylcoclaurine (10-100 μM) does not exhibit meaningful mushroom tyrosinase inhibitory activity at tested concentrations[1].
(-)-N-methylcoclaurine is present in varying quantities across different parts and regional samples of dried Nelumbo nucifera flower buds, with the highest content detected in Thai petal samples (5.85 mg/g dry material)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-N-methylcoclaurine Related Antibodies
Molecular Weight

299.36

Formula

C18H21NO3
CAS No.
SMILES

OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC=C(O)C=C3
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)-N-methylcoclaurine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-N-methylcoclaurine5096-70-8(–)-(1R)-N-methylcoclaurineDrug DerivativeDrug derivativeLC-MS methodskin hyperpigmentation disordersmurine B16 melanoma 4A5 cellsNelumbo nuciferamelanoma cellsmelanogenesis inhibitorbenzylisoquinoline alkaloidmushroom tyrosinaseInhibitorinhibitorinhibit

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