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Cat. No.: HY-N7717

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(-)-N-methylcoclaurine

(Synonyms: (–)-(1R)-N-methylcoclaurine)

(-)-N-methylcoclaurine ((-)-(1R)-N-methylcoclaurine) is a benzylisoquinoline alkaloid and melanogenesis inhibitor with an IC₅₀ of 6.5 μM that can be found in the flower buds of Nelumbo nucifera. (-)-N-methylcoclaurine inhibits theophylline-stimulated melanogenesis in melanoma cells. (-)-N-methylcoclaurine can be used for the research of skin hyperpigmentation disorders.

For research use only. We do not sell to patients.

CAS No.: 5096-70-8
Formula: C₁₈H₂₁NO₃
Molecular Weight:299.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(-)-N-methylcoclaurine Chemical Structure

CAS No.: 5096-70-8

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

(-)-N-methylcoclaurine (3-30 μM) inhibits theophylline-stimulated melanogenesis in murine B16 melanoma 4A5 cells with an IC₅₀ of 6.5 μM, without notable cytotoxicity at effective concentrations^[1].
(-)-N-methylcoclaurine (10-100 μM) does not exhibit meaningful mushroom tyrosinase inhibitory activity at tested concentrations^[1].
(-)-N-methylcoclaurine is present in varying quantities across different parts and regional samples of dried Nelumbo nucifera flower buds, with the highest content detected in Thai petal samples (5.85 mg/g dry material)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5096-70-8
Molecular Weight 299.36
Formula C₁₈H₂₁NO₃
SMILES

OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC=C(O)C=C3
Synonyms

(–)-(1R)-N-methylcoclaurine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Morikawa T, et al. Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity. Molecules. 2016;21(7):930. Published 2016 Jul 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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