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Cat. No.: HY-W414915R

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Valsartan methyl ester (Standard)

(Synonyms: CGP 48933 methyl ester (Standard))

Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 137863-17-3
Formula: C₂₅H₃₁N₅O₃
Molecular Weight:449.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Valsartan methyl ester (Standard) Chemical Structure

CAS No.: 137863-17-3

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 137863-17-3
Molecular Weight 449.55
Formula C₂₅H₃₁N₅O₃
SMILES

COC([C@H](C(C)C)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2)=O
Synonyms

CGP 48933 methyl ester (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Bühlmayer P, et al., Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(1): 29-34.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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