2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3823):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W659059
    N-Methyl-1-phenylpropan-1-amine hydrochloride
    N-Methyl-1-phenylpropan-1-amine hydrochloride is structurally categorized as a benzylamine.
    N-Methyl-1-phenylpropan-1-amine hydrochloride
  • HY-N17477
    3β,5α-Dihydroxy-6β-methoxyergosta-7,22-diene
    3β,5α-Dihydroxy-6β-methoxyergosta-7,22-diene is a natural product that can be found in animal bile.
    3β,5α-Dihydroxy-6β-methoxyergosta-7,22-diene
  • HY-101657
    Clocoumarol
    Clocoumarol is an active compound.
    Clocoumarol
  • HY-N16966
    Acropyrone
    Acropyrone is a natural phenolic compound.
    Acropyrone
  • HY-136997
    M-5MPEP
    M-5MPEP is an active compound.
    M-5MPEP
  • HY-W353474
    iso-Dehydrozingerone
    iso-Dehydrozingerone is a dehydrozingerone analog. iso-Dehydrozingerone exhibits moderate in vitro cytotoxic activity against human tumor cells, with IC50 values of 10.0 μg/mL, 8.2 μg/mL and >10 μg/mL against human nasopharyngeal carcinoma cells, multidrug-resistant nasopharyngeal carcinoma cells and human lung cancer cells, respectively. iso-Dehydrozingerone can be used in studies related to nasopharyngeal carcinoma, multidrug-resistant nasopharyngeal carcinoma and lung cancer.
    iso-Dehydrozingerone
  • HY-113594
    ICI 200355
    ICI 200355 is an active compound.
    ICI 200355
  • HY-N9772
    Platyphyllonol-5-O-β-D-xylopyranoside
    Platyphyllonol-5-O-β-D-xylopyranoside is a natural phenolic compound.
    Platyphyllonol-5-O-β-D-xylopyranoside
  • HY-116487
    R-18893
    R-18893 is an active compound.
    R-18893
  • HY-133623
    1,1,1-Tribromoacetone
    1,1,1-Tribromoacetone is a tribromide product based on bromoacetone.
    1,1,1-Tribromoacetone
  • HY-N6898
    3-O-Acetylbufotalin
    3-O-Acetylbufotalin is a derivate of bufadienolide, with anti-cancer activity.
    3-O-Acetylbufotalin
  • HY-178822
    AQ-13
    AQ-13 (Compound 7) is a Chloroquine (HY-17589A) analogue with anti-breast cancer property. AQ-13 shows antiproliferative activities against MDA-MB231 and MCF7 with GI50 of 27.81 and 17.85 μM. AQ-13 shows low cytotoxicity against non-cancerous breast epithelial cells MCF10A (GI50 = 65.26 μM). AQ-13 can be used for the research of breast cancer.
    AQ-13
  • HY-117618
    KF-14124
    KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency.
    KF-14124
  • HY-N7988A
    (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate
    (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate is a polyacetylene found in the rhizomes of Atractylodes lancea. (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate shows no inhibitory activity against 5-lipoxygenase and COX-1 in in vitro assays at tested concentrations.
    (E)-4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate
  • HY-N16840
    4'-Hydroxy-7,8-methylenedioxyhomoisoflavan
    4'-Hydroxy-7,8-methylenedioxyhomoisoflavan is a natural flavonoid.
    4'-Hydroxy-7,8-methylenedioxyhomoisoflavan
  • HY-W269511
    NW-1689
    		99.54%
    NW-1689 is a process-related impurity of safinamide mesilate (SAFM). SAFM can be used for the study of Parkinson's disease (PD). It is a highly selective and reversible inhibitor of monoamine oxidase-B (MAO-B) and also blocks sodium channels and N-type calcium channels. These effects of SAFM help reduce the breakdown of dopamine and inhibit the release of glutamate. NW-1689 has a similar chemical structure to SAFM and has some similar pharmacological effects as SAFM, and can be used in Parkinson's disease research.
    NW-1689
  • HY-180370
    Nitromemantine
    Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.
    Nitromemantine
  • HY-117850
    TAK 187
    TAK 187 is an active compound.
    TAK 187
  • HY-173539
    C24:1 1-Deoxyceramide (m18:1(14Z)/24:1)
    C24:1 1-Deoxyceramide (m18:1(14Z)/24:1) (C24:1 Ceramide (m18:1/24:1)) is an analog of ceramide.
    C24:1 1-Deoxyceramide (m18:1(14Z)/24:1)
  • HY-P11622
    Gramicidin S analogue 9
    Gramicidin S analogue 9 is a bactericidal agent that can be found as a cyclic peptide analogue. Gramicidin S analogue 9 disrupts bacterial cell membranes. Gramicidin S analogue 9 can be used for the research of methicillin-resistant staphylococcus aureus infection.
    Gramicidin S analogue 9