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Cat. No.: HY-P11622

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Gramicidin S analogue 9

Gramicidin S analogue 9 is a bactericidal agent that can be found as a cyclic peptide analogue. Gramicidin S analogue 9 disrupts bacterial cell membranes. Gramicidin S analogue 9 can be used for the research of methicillin-resistant staphylococcus aureus infection.

For research use only. We do not sell to patients.

CAS No.: 3106317-27-2
Formula: C₆₂H₉₄N₁₄O₁₀
Molecular Weight:1195.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gramicidin S analogue 9 Chemical Structure

CAS No.: 3106317-27-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Gramicidin S analogue 9 (0.125-256 μg/mL; 16-24 h) inhibits growth of MSSA ATCC 29213 and MRSA ATCC USA300 with an MIC of 2 μg/mL, has an HC₅₀ of 39.31 μg/mL in human red blood cells, an IC₅₀ of 22.36 μg/mL in HEK-293 cells, and a therapeutic index of 19.66^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3106317-27-2
Molecular Weight 1195.50
Formula C₆₂H₉₄N₁₄O₁₀
Sequence

Cyclo({d-Trp}-Ala-{Tle}-{Orn}-Leu-{d-Trp}-Ala-{Tle}-{Orn}-Leu)
Sequence Shortening

Cyclo({d-Trp}-A-{Tle}-{Orn}-L-{d-Trp}-A-{Tle}-{Orn}-L)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kalyvas JT, et al. Machine-Learning Approach to Increase the Potency and Overcome the Hemolytic Toxicity of Gramicidin S. J Med Chem. 2025;68(15):16093-16102. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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