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  3. Drug Derivative
  4. iso-Dehydrozingerone

iso-Dehydrozingerone is a dehydrozingerone analog. iso-Dehydrozingerone exhibits moderate in vitro cytotoxic activity against human tumor cells, with IC50 values of 10.0 μg/mL, 8.2 μg/mL and >10 μg/mL against human nasopharyngeal carcinoma cells, multidrug-resistant nasopharyngeal carcinoma cells and human lung cancer cells, respectively. iso-Dehydrozingerone can be used in studies related to nasopharyngeal carcinoma, multidrug-resistant nasopharyngeal carcinoma and lung cancer.

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iso-Dehydrozingerone

iso-Dehydrozingerone Chemical Structure

CAS No. : 22214-39-7

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iso-Dehydrozingerone Related Antibodies

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Description

iso-Dehydrozingerone is a dehydrozingerone analog. iso-Dehydrozingerone exhibits moderate in vitro cytotoxic activity against human tumor cells, with IC50 values of 10.0 μg/mL, 8.2 μg/mL and >10 μg/mL against human nasopharyngeal carcinoma cells, multidrug-resistant nasopharyngeal carcinoma cells and human lung cancer cells, respectively. iso-Dehydrozingerone can be used in studies related to nasopharyngeal carcinoma, multidrug-resistant nasopharyngeal carcinoma and lung cancer[1].

In Vitro

Iso-Dehydrozingerone (Compound 7) (2 days) inhibits the proliferation of human nasopharyngeal carcinoma KB cells with an IC50 of 10.0 μg/mL; it also inhibits the proliferation of human multidrug-resistant nasopharyngeal carcinoma KB-VCR cells with an IC50 of 8.2 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

iso-Dehydrozingerone Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human nasopharyngeal carcinoma KB cells, multidrug-resistant human nasopharyngeal carcinoma KB-VCR cells, human lung carcinoma A549 cells
Concentration: Concentrations to determine IC50 values
Incubation Time: 2 days
Result: Inhibited replication of KB cells with an IC50 of 10.0 μg/mL.
Inhibited replication of KB-VCR cells with an IC50 of 8.2 μg/mL.
Showed no measurable activity against A549 cells (IC50 >10 μg/mL).
Molecular Weight

192.21

Formula

C11H12O3
CAS No.
SMILES

C(=C/C(C)=O)\C1=CC(O)=C(OC)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iso-Dehydrozingerone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iso-Dehydrozingerone22214-39-7Drug DerivativeDrug derivativeKB-VCR cellslung carcinomaKB cellshuman nasopharyngeal carcinoma cellsA549 cellsmultidrug-resistant nasopharyngeal carcinomahuman lung carcinoma cellsInhibitorinhibitorinhibit

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HY-W353474
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