iso-Dehydrozingerone
iso-Dehydrozingerone is a dehydrozingerone analog. iso-Dehydrozingerone exhibits moderate in vitro cytotoxic activity against human tumor cells, with IC50 values of 10.0 μg/mL, 8.2 μg/mL and >10 μg/mL against human nasopharyngeal carcinoma cells, multidrug-resistant nasopharyngeal carcinoma cells and human lung cancer cells, respectively. iso-Dehydrozingerone can be used in studies related to nasopharyngeal carcinoma, multidrug-resistant nasopharyngeal carcinoma and lung cancer.
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- CAS No.: 22214-39-7
- Formule: C11H12O3
- Masse moléculaire:192.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
0.11 μM
Compound: 2c
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Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
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[PMID: 31257875] |
| K562 | IC50 |
42 μM
Compound: 4z
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In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line
In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line
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10.1016/S0960-894X(97)10147-0 |
| KB | IC50 |
10 μg/mL
Compound: 7
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Cytotoxicity against human KB cells after 2 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 2 days by sulforhodamine B assay
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[PMID: 17067159] |
| KB | IC50 |
8.2 μg/mL
Compound: 7
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Cytotoxicity against multidrug-resistant human KB-VCR cells after 2 days by sulforhodamine B assay
Cytotoxicity against multidrug-resistant human KB-VCR cells after 2 days by sulforhodamine B assay
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[PMID: 17067159] |
In Vitro
Iso-Dehydrozingerone (Compound 7) (2 days) inhibits the proliferation of human nasopharyngeal carcinoma KB cells with an IC50 of 10.0 μg/mL; it also inhibits the proliferation of human multidrug-resistant nasopharyngeal carcinoma KB-VCR cells with an IC50 of 8.2 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human nasopharyngeal carcinoma KB cells, multidrug-resistant human nasopharyngeal carcinoma KB-VCR cells, human lung carcinoma A549 cells
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Concentration:Concentrations to determine IC50 values
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Incubation Time:2 days
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Result:Inhibited replication of KB cells with an IC50 of 10.0 μg/mL.
Inhibited replication of KB-VCR cells with an IC50 of 8.2 μg/mL.
Showed no measurable activity against A549 cells (IC50 >10 μg/mL).
Chemical Information
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CAS No. 22214-39-7
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Masse moléculaire 192.21
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Formule C11H12O3
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SMILES
C(=C/C(C)=O)\C1=CC(O)=C(OC)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iso-Dehydrozingerone Related Classifications
HY-W353474 Related Classifications
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