2. Membrane Transporter/Ion Channel Neuronal Signaling Others
  3. iGluR Drug Derivative
  4. Nitromemantine

Nitromemantine  (Synonyms: NitroSynapsin; YQW-036; NMI-6979)

Cat. No.: HY-180370
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Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.

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Nitromemantine

Nitromemantine Chemical Structure

CAS No. : 765890-91-3

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Nitromemantine Related Antibodies

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Description

Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke[1].

Molecular Weight

268.35

Formula

C14H24N2O3
CAS No.
SMILES

CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Nitromemantine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitromemantine765890-91-3NitroSynapsin YQW-036 NMI-6979YQW036YQW 036YQW-036NMI6979NMI 6979NMI-6979iGluRDrug DerivativeIonotropic glutamate receptorsDrug derivativeNMDAR antagonistNitroMemantinecerebrovascular diseaseS-nitrosylationopen-channel blockneuroprotectionhypoxiasynaptic sparingischemic strokeallosteric modulationInhibitorinhibitorinhibit

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