Nitromemantine
Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.
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- CAS No.: 765890-91-3
- Formula: C14H24N2O3
- Molecular Weight:268.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 765890-91-3
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Molecular Weight 268.35
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Formula C14H24N2O3
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SMILES
CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
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Synonyms
NitroSynapsin; YQW-036; NMI-6979
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nitromemantine Related Classifications
Cat. No.: HY-180370
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- Nitromemantine
- 765890-91-3
- NitroSynapsin
- YQW-036
- NMI-6979
- YQW036
- YQW 036
- YQW-036
- NMI6979
- NMI 6979
- NMI-6979
- iGluR
- Drug Derivative
- NMDAR antagonist
- NitroMemantine
- cerebrovascular disease
- S-nitrosylation
- open-channel block
- neuroprotection
- hypoxia
- synaptic sparing
- ischemic stroke
- allosteric modulation
- Inhibitor
- inhibitor
- inhibit