765890-91-3
Chemical Structure
Nitromemantine
Synonym(s): NitroSynapsin; YQW-036; NMI-6979
- CAS No.: 765890-91-3
- Formula:C14H24N2O3
- Molecular Weight:268.35
IUPAC Name: 3-amino-5,7-diethyladamantan-1-yl nitrate
InChIKey: SENUTBBWBZZNRT-UHFFFAOYSA-N
SMILES: CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
Biological Activity: Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke[1].
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Nitromemantine | Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke. | |||||||||||||||||||||
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Keywords
