2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3822):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106074
    Mexiprostil
    Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 (HY-B0131). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine (HY-B1204) and Bethanechol (HY-B0406) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin (HY-A0261) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers.
    Mexiprostil
  • HY-186000
    Paclitaxel-maleimide
    Paclitaxel-maleimide is Paclitaxel (HY-B0015) modified with a maleimide linker. Paclitaxel-maleimide shows strong BSA binding ability. Paclitaxel-maleimide can be used in tumor research.
    Paclitaxel-maleimide
  • HY-17661
    Depiperazine-DM3189
    Depiperazine-DM3189 is a derivative of LDN193189 (HY-12071). LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva.
    Depiperazine-DM3189
  • HY-N17044
    4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol
    4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol is a natural phenolic compound.
    4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol
  • HY-N13285
    (-)-Epigallocatechin-4'-O-methylether
    (-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury.
    (-)-Epigallocatechin-4'-O-methylether
  • HY-173541
    C6 Dihydro 1-deoxyceramide (m18:0/6:0)
    C6 Dihydro 1-deoxyceramide (m18:0/6:0) (C6 Dihydro ceramide (m18:0/6:0)) is an analog of ceramide.
    C6 Dihydro 1-deoxyceramide (m18:0/6:0)
  • HY-158767
    Dehydro amlodipine fumarate
    		99.50%
    Dehydro amlodipine fumarate is a derivative of Dehydro amlodipine and is one of the forced degradation products of Dehydro amlodipine during oxidation and acid degradation.
    Dehydro amlodipine fumarate
  • HY-N16726
    Petasalbin
    Petasalbin is a natural sesquiterpene.
    Petasalbin
  • HY-P4724
    (β-Asp28)-Exenatide
    (β-Asp28)-Exenatide is a potential degradation product of exenatide produced by the formation and cleavage of asparagine.
    (β-Asp28)-Exenatide
  • HY-11033
    DNP-60502
    DNP-60502 is a phthalide derivative. DNP-60502 exhibits potent glucose production inhibitory activity by targeting key regulatory enzymes in hepatic glucose metabolism. DNP-60502 can be used for the study of type 2 diabetes.
    DNP-60502
  • HY-182022
    ZLWH-67
    ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models.
    ZLWH-67
  • HY-139360
    MDPT(tBuONE)
    3',4'-Methylenedioxy-N-tert-butylcathinone hydrochloride is structurally categorized as a drug derivative.
    MDPT(tBuONE)
  • HY-N17875
    Demethylsalvicanol
    Demethylsalvicanol ((+)-Demethylsalvicanol), a diterpene, is a anticancer agent with an IC50 of 0.71 μg/mL against P388 murine leukemia cells. Demethylsalvicanol induces cytotoxic activity against leukemia cells and insect Sf9 cells. Demethylsalvicanol acts as an antifeedant against Leptinotarsa decemlineata. Demethylsalvicanol can be used for the research of leukemia.
    Demethylsalvicanol
  • HY-186144
    WMK-2
    WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer.
    WMK-2
  • HY-103641AR
    (2S)-Octyl-α-hydroxyglutarate (Standard)
    CVT-2738 (Standard) is the analytical standard of CVT-2738. This product is intended for research and analytical applications. CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities.
    (2S)-Octyl-α-hydroxyglutarate (Standard)
  • HY-125368
    LB30870
    LB30870 is an active compound.
    LB30870
  • HY-W1121922
    (±)-Mintlactone
    (±)-Mintlactone is a member of benzofurans that can be found in the essential oil of Menthu piperitu L. (peppermint oil).
    (±)-Mintlactone
  • HY-N8717
    Sculponeatin K
    Sculponeatin K is a natural diterpene.
    Sculponeatin K
  • HY-178102
    SKLB-0266
    SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6.
    SKLB-0266
  • HY-19678C
    Trospectomycin dihydrochloride
    Trospectomycin (U-63366F) dihydrochloride, a Spectinomycin (HY-B1828) analogue, is a broad-spectrum antibacterial agent.
    Trospectomycin dihydrochloride