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United States

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Art. -Nr.: HY-178102

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SKLB-0266

SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6.

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Formel: C₃₃H₄₇N₅O₂
Molecular Weight:545.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

SKLB-0266 Chemical Structure

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Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6^[1].

Chemical Information

Molecular Weight 545.76
Formel C₃₃H₄₇N₅O₂
SMILES

O=C(NCCCC(NC1=CC=C(C2=CN=CC(CN(C)CCN(C)C)=C2)C=C1)=O)CC34C[C@H](C[C@@H]5C4)C[C@H](C5)C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang H, et al. Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6). Bioorg Chem. 2024 Jul;148:107439. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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