country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-178102

Copy Link Print Information

SKLB-0266

SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6.

For research use only. We do not sell to patients.

Formula: C₃₃H₄₇N₅O₂
Molecular Weight:545.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

SKLB-0266 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6^[1].

Chemical Information

Molecular Weight 545.76
Formula C₃₃H₄₇N₅O₂
SMILES

O=C(NCCCC(NC1=CC=C(C2=CN=CC(CN(C)CCN(C)C)=C2)C=C1)=O)CC34C[C@H](C[C@@H]5C4)C[C@H](C5)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang H, et al. Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6). Bioorg Chem. 2024 Jul;148:107439. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote