(-)-Epigallocatechin-4'-O-methylether
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury.
For research use only. We do not sell to patients.
- CAS No.: 17291-05-3
- Formula: C16H16O7
- Molecular Weight:320.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(-)-Epigallocatechin-4'-O-methylether can specifically bind to human serum albumin[1].
(-)-Epigallocatechin-4'-O-methylether (compound 4) (10 μM; 30 min) potently scavenges DPPH radicals with an SC50 of 10 μM in a cell-free assay[4].
(-)-Epigallocatechin-4'-O-methylether (10-100 μM; 40 h) significantly inhibits CCl4-induced cytotoxicity in primary cultured mouse hepatocytes at 100 μM, with no significant effect at 10 μM or 30 μM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:primary cultured mouse hepatocytes
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Concentration:10, 30, 100 μM
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Incubation Time:40 h
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Result:Inhibited CCl4-induced cytotoxicity in primary cultured mouse hepatocytes at 100 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY mice (male, 5 weeks old)[4]
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Dosage:100 mg/kg
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Administration:p.o.; single dose
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Result:Significantly suppressed CCl4-induced serum GOT and GPT elevations.
Significantly inhibited CCl4-induced TBA-RS formation in the liver in a dose-dependent manner, with strong reduction of TBA-RS levels relative to control.
Chemical Information
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CAS No. 17291-05-3
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Molecular Weight 320.30
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Formula C16H16O7
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SMILES
O[C@H]1[C@H](OC=2C(C1)=C(O)C=C(O)C2)C3=CC(O)=C(OC)C(O)=C3
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Synonyms
(-)-EGC-4'-O-ME
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Takahashi T, et al. Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition. PLoS One. 2018;13(10):e0204856. Published 2018 Oct 11. [Content Brief]
[2]. Cameron AR, et al. Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a. Aging Cell. 2008 Jan;7(1):69-77. [Content Brief]
[3]. Gonzalez JG, et al. Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis. J Ethnopharmacol. 1982;5(1):73-77. [Content Brief]
[4]. Yoshikawa M, et al. Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull. 2002;25(1):72-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Epigallocatechin-4'-O-methylether Related Classifications
HY-N13285 Related Classifications
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