(-)-Epigallocatechin-4'-O-methylether  (Synonyms: (-)-EGC-4'-O-ME)

(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury^[1][2][3][4].

(-)-Epigallocatechin-4'-O-methylether can specifically bind to human serum albumin^[1].
(-)-Epigallocatechin-4'-O-methylether (compound 4) (10 μM; 30 min) potently scavenges DPPH radicals with an SC₅₀ of 10 μM in a cell-free assay^[4].
(-)-Epigallocatechin-4'-O-methylether (10-100 μM; 40 h) significantly inhibits CCl₄-induced cytotoxicity in primary cultured mouse hepatocytes at 100 μM, with no significant effect at 10 μM or 30 μM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Epigallocatechin-4'-O-methylether (compound 4) (100 mg/kg; p.o.; single dose) potently inhibits CCl₄-induced liver injury in male ddY mice, as evidenced by reduced serum transaminase levels and liver lipid peroxidation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

320.30

C₁₆H₁₆O₇

17291-05-3

O[C@H]1[C@H](OC=2C(C1)=C(O)C=C(O)C2)C3=CC(O)=C(OC)C(O)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Takahashi T, et al. Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition. PLoS One. 2018;13(10):e0204856. Published 2018 Oct 11.

  [2]. Cameron AR, et al. Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a. Aging Cell. 2008 Jan;7(1):69-77.

  [3]. Gonzalez JG, et al. Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis. J Ethnopharmacol. 1982;5(1):73-77.

  [4]. Yoshikawa M, et al. Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull. 2002;25(1):72-76.