2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Others Cell Cycle/DNA Damage
  3. Bacterial Reactive Oxygen Species (ROS) Drug Derivative DNA/RNA Synthesis
  4. ZLWH-67

ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models.

For research use only. We do not sell to patients.

ZLWH-67

ZLWH-67 Chemical Structure

CAS No. : 3083425-49-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ZLWH-67 Related Antibodies

Top Publications Citing Use of Products

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models[1].

In Vitro

ZLWH-67 (24 h) exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL) and S. pneumoniae (MIC = 16 μg/mL); its MBC against MRSA USA300 is 4 μg/mL, and it shows no activity against the tested Gram-negative bacteria or fungi[1].
ZLWH-67 (16-256 μg/mL; 1 h) shows no hemolytic toxicity to sheep red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZLWH-67 Related Antibodies
In Vivo

ZLWH-67 (0.4 mg/kg; topical; twice daily; 4 days) significantly reduces MRSA bacterial burden, proinflammatory cytokine levels, and tissue damage in a mouse skin infection model[1].
ZLWH-67 (100 mg/kg/day) significantly improves survival, reduces MRSA bacterial burden, lowers proinflammatory cytokine levels, and mitigates tissue damage in mouse lethal and sublethal pneumonia infection models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6−8 weeks old)[1]
Dosage: 0.4 mg/kg
Administration: topical; twice daily; 4 days
Result: Reduced bacterial burden in skin tissues (log10 CFU/0.1 g tissue decreased relative to controls, P=0.0364).
Promoted wound closure relative to controls.
Significantly reduced levels of proinflammatory cytokines TNF-α, IL-6, and IL-1β in skin tissues (P=0.0009, P=0.0239, P=0.0201 respectively).
Alleviated skin tissue pathology including necrosis, inflammatory exudate, and hemorrhage.
Animal Model: C57BL/6 (female, 6−8 weeks old)[1]
Dosage: 100 mg/kg/day
Administration: daily
Result: In the lethal pneumonia model, significantly improved mouse survival rate relative to controls.
Alleviated infection-related clinical symptoms and promoted body weight recovery relative to controls.
In the sublethal pneumonia model, reduced bacterial burden in lung tissues (log10 CFU/mL tissue decreased relative to controls, P=0.0047).
Significantly reduced levels of proinflammatory cytokines TNF-α, IL-6, and IL-1β in lung tissues (P=0.0008, P=0.0016, P<0.0001 respectively).
Alleviated lung tissue pathology including alveolar wall thickening, epithelial desquamation, inflammatory infiltration, and hemorrhage.
Molecular Weight

428.44

Formula

C24H20N4O4
CAS No.
SMILES

O=C(C1=CC2=C(C=C1)C3=C(C(NC(C4CC4)=O)=NC=C3)N2)NCC5=CC=C(OCO6)C6=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ZLWH-67 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLWH-673083425-49-1ZLWH67ZLWH 67BacterialReactive Oxygen Species (ROS)Drug DerivativeDNA/RNA SynthesisDrug derivativeoxidative stressDNA synthesisMSSAenergy metabolismmouse pneumonia infection modelsbiofilm formationcell membrane integritycytoplasmic DNA leakagemouse skin infection modelsMRSAInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ZLWH-67
Cat. No.:
HY-182022
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.