3083425-49-1
Chemical Structure
ZLWH-67
- CAS No.: 3083425-49-1
- Formula:C24H20N4O4
- Molecular Weight:428.44
InChIKey: ZVZGDDBFWAZTOX-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C=C1)C3=C(C(NC(C4CC4)=O)=NC=C3)N2)NCC5=CC=C(OCO6)C6=C5
Biological Activity: ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models[1].
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ZLWH-67 | ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models. | |||||||||||||||||||||
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Keywords
