WMK-2
WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2814563-63-6
- Formula: C38H49BrNO6P
- Molecular Weight:726.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
WMK-2 (37b) showed potent and broad-spectrum antiproliferative activity across numerous cancer cell lines. It potently inhibited MDA-MB-231, HCT116, T47D, HepG2, HeLa, HEK293, MCF7, PLC, U2OS, and Huh7 cells with IC50 values of 0.38, 0.6, 0.62, 0.7, 1.6, 1.6, 2.4, 2.7, 3.4, and 3.8 μM, respectively. Meanwhile, WMK-2 displayed favorable selectivity toward normal cells, with IC50 values of 4.6 μM (NIH3T3), 5.2 μM (bEnd.3), and 9.5 μM (MDCK), corresponding to a selectivity index greater than 7.6[1].
WMK-2 (48 h) inhibits HeyA8 adherent ovarian cancer cell viability with an IC50 of 1.4 μM and HeyA8 ovarian cancer stem cell spheroid viability with an IC50 of 1.1 μM after 48 h of incubation, showing a selectivity index greater than 11 relative to non-cancerous NIH3T3 cells[1].
WMK-2 induces ferroptosis in both HeyA8 ovarian cancer stem cells and MDA-MB-231 breast cancer cells[1].
WMK-2 (1 μM; 6 h) induces significant lipid ROS generation in MDA-MB-231 breast cancer cells, confirming ferroptosis-associated lipid peroxidation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (female, HEYA8 CSC xenograft model)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:i.p.
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Result:Effectively inhibited ovarian tumor growth compared with vehicle control.
Showed well-tolerated safety profile with no abnormal behavior or weight loss noted during treatment period.
Chemical Information
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CAS No. 2814563-63-6
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Molecular Weight 726.68
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Formula C38H49BrNO6P
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SMILES
CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=O)CC3)OO2)CC1.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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