WMK-2
WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer.
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- CAS. Nr.: 2814563-63-6
- Formel: C38H49BrNO6P
- Molecular Weight:726.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
WMK-2 (37b) showed potent and broad-spectrum antiproliferative activity across numerous cancer cell lines. It potently inhibited MDA-MB-231, HCT116, T47D, HepG2, HeLa, HEK293, MCF7, PLC, U2OS, and Huh7 cells with IC50 values of 0.38, 0.6, 0.62, 0.7, 1.6, 1.6, 2.4, 2.7, 3.4, and 3.8 μM, respectively. Meanwhile, WMK-2 displayed favorable selectivity toward normal cells, with IC50 values of 4.6 μM (NIH3T3), 5.2 μM (bEnd.3), and 9.5 μM (MDCK), corresponding to a selectivity index greater than 7.6[1].
WMK-2 (48 h) inhibits HeyA8 adherent ovarian cancer cell viability with an IC50 of 1.4 μM and HeyA8 ovarian cancer stem cell spheroid viability with an IC50 of 1.1 μM after 48 h of incubation, showing a selectivity index greater than 11 relative to non-cancerous NIH3T3 cells[1].
WMK-2 induces ferroptosis in both HeyA8 ovarian cancer stem cells and MDA-MB-231 breast cancer cells[1].
WMK-2 (1 μM; 6 h) induces significant lipid ROS generation in MDA-MB-231 breast cancer cells, confirming ferroptosis-associated lipid peroxidation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (female, HEYA8 CSC xenograft model)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:i.p.
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Result:Effectively inhibited ovarian tumor growth compared with vehicle control.
Showed well-tolerated safety profile with no abnormal behavior or weight loss noted during treatment period.
Chemical Information
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CAS. Nr. 2814563-63-6
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Molecular Weight 726.68
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Formel C38H49BrNO6P
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SMILES
CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=O)CC3)OO2)CC1.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
WMK-2 Related Classifications
HY-186144 Related Classifications
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