2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Others
  3. Ferroptosis Reactive Oxygen Species (ROS) Drug Derivative
  4. WMK-2

WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

WMK-2

WMK-2 Chemical Structure

CAS No. : 2814563-63-6

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WMK-2 Related Antibodies

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Description

WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer[1].

In Vitro

WMK-2 (37b) showed potent and broad-spectrum antiproliferative activity across numerous cancer cell lines. It potently inhibited MDA-MB-231, HCT116, T47D, HepG2, HeLa, HEK293, MCF7, PLC, U2OS, and Huh7 cells with IC50 values of 0.38, 0.6, 0.62, 0.7, 1.6, 1.6, 2.4, 2.7, 3.4, and 3.8 μM, respectively. Meanwhile, WMK-2 displayed favorable selectivity toward normal cells, with IC50 values of 4.6 μM (NIH3T3), 5.2 μM (bEnd.3), and 9.5 μM (MDCK), corresponding to a selectivity index greater than 7.6[1].
WMK-2 (48 h) inhibits HeyA8 adherent ovarian cancer cell viability with an IC50 of 1.4 μM and HeyA8 ovarian cancer stem cell spheroid viability with an IC50 of 1.1 μM after 48 h of incubation, showing a selectivity index greater than 11 relative to non-cancerous NIH3T3 cells[1].
WMK-2 induces ferroptosis in both HeyA8 ovarian cancer stem cells and MDA-MB-231 breast cancer cells[1].
WMK-2 (1 μM; 6 h) induces significant lipid ROS generation in MDA-MB-231 breast cancer cells, confirming ferroptosis-associated lipid peroxidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WMK-2 Related Antibodies
In Vivo

WMK-2 (37b) (5-10 mg/kg; i.p.) effectively inhibited tumor growth in both MDA-MB-231 breast cancer and HEYA8 CSC ovarian cancer xenograft nude mice, with no observed histopathological abnormalities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (female, HEYA8 CSC xenograft model)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.
Result: Effectively inhibited ovarian tumor growth compared with vehicle control.
Showed well-tolerated safety profile with no abnormal behavior or weight loss noted during treatment period.
Molecular Weight

726.68

Formula

C38H49BrNO6P
CAS No.
SMILES

CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=O)CC3)OO2)CC1.[Br-]
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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WMK-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WMK-22814563-63-6WMK2WMK 2FerroptosisReactive Oxygen Species (ROS)Drug DerivativeDrug derivativeovarian cancercolon cancercancer cellscancer stem cellsferroptosisHeLaliver cancercervical cancerMDA-MB-231breast cancerInhibitorinhibitorinhibit

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