Demethylsalvicanol
Demethylsalvicanol ((+)-Demethylsalvicanol), a diterpene, is a anticancer agent with an IC50 of 0.71 μg/mL against P388 murine leukemia cells. Demethylsalvicanol induces cytotoxic activity against leukemia cells and insect Sf9 cells. Demethylsalvicanol acts as an antifeedant against Leptinotarsa decemlineata. Demethylsalvicanol can be used for the research of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 124960-41-4
- Formula: C20H30O3
- Molecular Weight:318.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
10.6 μM
Compound: 10
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Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess assay
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[PMID: 27933899] |
Demethylsalvicanol (48 h) exhibits cytotoxic activity against murine P388 leukemia cells with an IC50 of 0.71 μg/mL[1].
Demethylsalvicanol (48 h) potently and selectively inhibits viability of Spodoptera frugiperda Sf9 insect cells, with no activity against mammalian Chinese hamster ovary CHO cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 124960-41-4
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Molecular Weight 318.45
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Formula C20H30O3
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SMILES
O[C@@]12[C@](CCC3=CC(C(C)C)=C(O)C(O)=C3C2)([H])C(C)(CCC1)C
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Synonyms
(+)-Demethylsalvicanol
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Aoyagi Y, et al. Semisynthesis of isetexane diterpenoid analogues and their cytotoxic activity. Chem Pharm Bull (Tokyo). 2006;54(11):1602-1604. [Content Brief]
[2]. Fraga BM, et al. Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity. J Agric Food Chem. 2005;53(13):5200-5206. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Demethylsalvicanol Related Classifications
HY-N17875 Related Classifications
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