Semisynthesis of isetexane diterpenoid analogues and their cytotoxic activity

  • Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1602-4. doi: 10.1248/cpb.54.1602.
Yutaka Aoyagi  1 ,  Yoshinao Takahashi ,  Haruhiko Fukaya ,  Koichi Takeya ,  Ritsuo Aiyama ,  Takeshi Matsuzaki ,  Shusuke Hashimoto ,  Teruo Kurihara
Affiliations
  • 1. School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Tokyo, Japan.
PMID: 17077562 DOI: 10.1248/cpb.54.1602
Abstract

Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.

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