Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (542)
Related Products (542)
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Ornidazole (Levo-)
0 ImagesSynonyms: (S)-Ornidazole; LevornidazoleLevo-ornidazole ((S)-Ornidazole) is the L-isomer of Ornidazole. Ornidazole (Levo-) increases GAD 65/67 expression and decreases brain Glu/GABA ratio. Ornidazole (Levo-) has a mild sedative effect. Levo-ornidazole can be used in the research of anti-anaerobic and anti-parasitic agents.
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Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside
0 ImagesCat. No.: HY-113949ACAS No.: 20672-63-3Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is an enantiomer of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside. Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is a derivative of L-ribose.
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(1S,2S)-Bortezomib
0 ImagesCat. No.: HY-135396CAS No.: 1132709-14-8(1S,2S)-Bortezomib (Compound Imp-D (1S,2S)) is a diastereomeric impurity of Bortezomib (HY-10227).
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Prohydrojasmon racemate
0 ImagesSynonyms: n-Propyl dihydrojasmonateProhydrojasmon racemate (n-Propyl dihydrojasmonate) is the racemate of Prohydrojasmon. Prohydrojasmon is a synthesized plant growth regulator.
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(±)16(17)-EpDPA
0 ImagesCat. No.: HY-165071CAS No.: 155073-46-4Synonyms: (±)16,17 EDP; (±)16,17-Epoxy docosapentaenoic acid; (±)16,17-Epoxy DPA(±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA.
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(2R,3S)-Azelaprag
0 ImagesSynonyms: (2R,3S)-AMG 986(2R,3S)-Azelaprag ((2R,3S)-AMG 986) (Example 238.0) is a precursor of an apelin receptor agonist (EC50=12 nM) and an isomer of Azelaprag (HY-109111).
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(±)-Levomepromazine-d6
0 ImagesSynonyms: (±)-Methotrimeprazine-d6; dl-Methotrimeprazine-d6(±)-Levomepromazine-d6 ((±)-Methotrimeprazine-d6) is the deuterium labeled (±)-Levomepromazine (HY-19489). (±)-Levomepromazine ((±)-Methotrimeprazine) is the racemate of Levomepromazine (HY-B1693).
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(-)-Butin (Standard)
0 Images(-)-Butin (Standard) is the analytical standard of (-)-Butin (HY-N6020). This product is intended for research and analytical applications. (-)-Butin is a enantiomer of Butin (HY-N6020B). Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
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(1R)-GLP-1 receptor agonist 12
0 ImagesCat. No.: HY-153816ACAS No.: 2775376-51-5(1R)-GLP-1 receptor agonist 12 is the isomer of GLP-1 receptor agonist 12 (HY-153816).
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(S)-Zovegalisib
0 ImagesSynonyms: (S)-RLY-2608(S)-Zovegalisib ((S)-RLY-2608) is an S-enantiomer of of Zovegalisib (HY-153306). Zovegalisib is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity.
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(R)-PF-04991532
0 ImagesCat. No.: HY-100181BPurity: 98.04%(R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.
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(S)-TROX-1
0 Images(S)-TROX-1 is the S-enantiomer of TROX-1 (HY-120751). TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC50 value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain.
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R-(–)-Flecainide
0 ImagesR-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity.
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(2S,3R)-Brassinazole
0 Images(2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz.
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L-Cytidine
0 ImagesL-Cytidine is the L-configurational form of Cytidine (HY-B0158). L-Cytidine is a pyrimidine nucleoside and a component of RNA. Cytidine regulates glial glutamate cycling, affects cephalin metabolism, catecholamine synthesis and mitochondrial function. L-Cytidine interacts with HSA, which may alter the structure and function of HSA.
