(S)-Seco-Duocarmycin SA
Based on 1 Customer Validation
(S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356). Seco-Duocarmycin SA can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 152785-82-5
- Formula: C25H24ClN3O7
- Molecular Weight:513.93
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.008 nM
Compound: seco-DSA
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Cytotoxicity against mouse L1210 cells after 72 hrs by phosphatase assay
Cytotoxicity against mouse L1210 cells after 72 hrs by phosphatase assay
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[PMID: 23944748] |
(S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA, which can induce a concentration-dependent increase in apoptotic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152785-82-5
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Appearance Solid
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Molecular Weight 513.93
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Formula C25H24ClN3O7
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Color Light yellow to yellow
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SMILES
ClC[C@H]1C2=C(C=C(O)C3=C2C=C(C(OC)=O)N3)N(C(C4=CC5=CC(OC)=C(OC)C(OC)=C5N4)=O)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (194.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Morcos A, et al. Seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines. Int J Mol Sci. 2025;26(6):2766. Published 2025 Mar 19. [Content Brief]
[2]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007;129(35):10858-10869. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9458 mL | 9.7290 mL | 19.4579 mL | 48.6448 mL |
| 5 mM | 0.3892 mL | 1.9458 mL | 3.8916 mL | 9.7290 mL | |
| 10 mM | 0.1946 mL | 0.9729 mL | 1.9458 mL | 4.8645 mL | |
| 15 mM | 0.1297 mL | 0.6486 mL | 1.2972 mL | 3.2430 mL | |
| 20 mM | 0.0973 mL | 0.4864 mL | 0.9729 mL | 2.4322 mL | |
| 25 mM | 0.0778 mL | 0.3892 mL | 0.7783 mL | 1.9458 mL | |
| 30 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6215 mL | |
| 40 mM | 0.0486 mL | 0.2432 mL | 0.4864 mL | 1.2161 mL | |
| 50 mM | 0.0389 mL | 0.1946 mL | 0.3892 mL | 0.9729 mL | |
| 60 mM | 0.0324 mL | 0.1621 mL | 0.3243 mL | 0.8107 mL | |
| 80 mM | 0.0243 mL | 0.1216 mL | 0.2432 mL | 0.6081 mL | |
| 100 mM | 0.0195 mL | 0.0973 mL | 0.1946 mL | 0.4864 mL |
(S)-Seco-Duocarmycin SA Related Classifications
HY-129356A Related Classifications
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