Seco-Duocarmycin SA
Based on 1 publication(s) in Google Scholar
Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates.
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- CAS No.: 144667-38-9
- Formule: C25H24ClN3O7
- Masse moléculaire:513.93
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Duocarmycins |
DNA alkylator |
Seco-Duocarmycin SA (Compound seco-DSA) (0-0.05 nM) exhibits significant potency in glioblastoma multiforme (GBM) cell lines, LN18 (IC50 = 0.005 nM) and T98G (IC50 = 0.008 nM)[2].
Seco-Duocarmycin SA (0-1 nM, 72 h) inhibits cell proliferation in both LN18 (IC50 = 0.12 nM) and T98G (IC50 = 0.28 nM) cell lines[2].
Seco-Duocarmycin SA (0-0.28 nM, 0-24 h) achieves maximal efficacy within 8 h[2].
Seco-Duocarmycin SA (0.1-0.28 nM, 24-72 h) results in a significant decrease in the G1 phase accompanied by an increase in the S and G2/M phases in T98G and a significant increase in the G2/M phase in LN18 and T98G cells[2].
Seco-Duocarmycin SA (0.1-0.28 nM, 24 h) inhibits cell migration of LN18 and T98G[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LN18 and T98G
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Concentration:0, 0.2, 0.4, 0.6, 0.8, 1 nM
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Incubation Time:72 h
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Result:Inhibited cell viability in both LN18 (IC50 = 0.21 nM) and T98G (IC50 = 0.25 nM) cell lines.
Chemical Information
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CAS No. 144667-38-9
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Masse moléculaire 513.93
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Formule C25H24ClN3O7
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SMILES
O=C(C1=CC2=C3C(N(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)CC3CCl)=CC(O)=C2N1)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
2026 Feb 4;27(3):1532. PMID: 41683948
Pureté et documentation
Références
[2]. Morcos, A., et al., (2025). Seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines. International journal of molecular sciences, 26(6), 2766. [Content Brief]
[3]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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