2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. iGluR

iGluR

Ionotropic glutamate receptors

iGluR

Related Products

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iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Isoform Specific Products:

iGluR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169806
    Methalthiazide
    Methalthiazide enhances the activity of natural stimulators of AMPA receptors and can be used in the study of schizophrenia.
    Methalthiazide
  • HY-120811
    PF-04701475
    		Agonist
    PF-04701475 is a potent AMPA receptor potentiator with an EC50 of 123 nM. PF-04701475 can be used for the study of neurological disorders.
    PF-04701475
  • HY-W008038R
    NMDAR antagonist 3 (Standard)
    		Antagonist
    NMDAR antagonist 3 (Standard) is the analytical standard of NMDAR antagonist 3. This product is intended for research and analytical applications. NMDAR antagonist 3 (Compound 2) is an antagonist of the NMDA receptor. NMDAR antagonist 3 has a certain but weak inhibitory activity against the NR1A/2B subtype of the NMDA receptor.
    NMDAR antagonist 3 (Standard)
  • HY-W922811
    DL-Willardiine
    		Antagonist
    DL-Willardiine is an AMPA antagonist with an IC50 of 2 μM. DL-Willardiine can be utilized in psychotropic cccccc research.
    DL-Willardiine
  • HY-160931
    NMDA receptor modulator 8
    		Modulator
    NMDA receptor modulator 8 (Compound 3-6) is a modulator for NMDA receptor, with 50%-100% potentiation of NMDA receptor at 10 μM.
    NMDA receptor modulator 8
  • HY-104020B
    Philanthotoxin 74 diTFA
    		Antagonist
    Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
    Philanthotoxin 74 diTFA
  • HY-109046R
    Tulrampator (Standard)
    		Agonist
    Tulrampator (Standard) is the analytical standard of Tulrampator (HY-109046). This product is intended for research and analytical applications. Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.
    Tulrampator (Standard)
  • HY-B1283S
    Mephenesin-d3
    		Antagonist
    Mephenesin-d3 is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm.
    Mephenesin-d<sub>3</sub>
  • HY-108235BR
    (Rac)-Lanicemine (Standard)
    		Antagonist
    (Rac)-Lanicemine (Standard) is the analytical standard of (Rac)-Lanicemine. This product is intended for research and analytical applications. (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
    (Rac)-Lanicemine (Standard)
  • HY-15410A
    Gacyclidine hydrochloride
    		Antagonist
    Gacyclidine hydrochloride, a non competitive N-methyl-D-aspartate (NMDA) antagonist, can be used in the study of spinal cord injuries.
    Gacyclidine hydrochloride
  • HY-100456R
    ZL006 (Standard)
    		Inhibitor
    ZL006 (Standard) is the analytical standard of ZL006 (HY-100456). This product is intended for research and analytical applications. ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
    ZL006 (Standard)
  • HY-17456R
    Omberacetam (Standard)
    		Agonist
    Omberacetam (Standard) is the analytical standard of Omberacetam. This product is intended for research and analytical applications. Omberacetam (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
    Omberacetam (Standard)
  • HY-107512R
    Kynurenic acid sodium (Standard)
    		Antagonist
    Kynurenic acid (sodium) (Standard) is the analytical standard of Kynurenic acid (sodium). This product is intended for research and analytical applications. Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
    Kynurenic acid sodium (Standard)
  • HY-B0585S
    Piracetam-d8
    		Modulator
    Piracetam-d8 (UCB-6215-d8) is the deuterium labeled Piracetam. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
    Piracetam-d<sub>8</sub>
  • HY-B1283R
    Mephenesin (Standard)
    		Antagonist
    Mephenesin (Standard) is the analytical standard of Mephenesin. This product is intended for research and analytical applications. Mephenesin is an NMDA receptor antagonist and Mephenesin is a central muscle relaxant.
    Mephenesin (Standard)
  • HY-102053R
    Apimostinel (Standard)
    		Agonist
    Apimostinel (Standard) is the analytical standard of Apimostinel (HY-102053). This product is intended for research and analytical applications. Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.
    Apimostinel (Standard)
  • HY-B0122SS1
    Topiramate-13C6-1
    		Antagonist
    Topiramate-13C6-1 (McN 4853-13C6-1; RWJ 17021-13C6-1) is 13C-labeled Topiramate (HY-B0122).
    Topiramate-<sup>13</sup>C<sub>6</sub>-1
  • HY-100811R
    7-Chlorokynurenic acid (Standard)
    		Antagonist
    7-Chlorokynurenic acid (Standard) is the analytical standard of 7-Chlorokynurenic acid. This product is intended for research and analytical applications. 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
    7-Chlorokynurenic acid (Standard)
  • HY-W051199
    O-Phosphono-L-homoserine
    		Antagonist
    O-Phosphono-L-homoserine (o-Phosphohomoserine) is an intermediate in threonine synthesis in bacteria and plants, and can also be hijacked by MetM in some Streptomyces species to enter a novel methionine synthesis pathway. O-Phosphono-L-homoserine acts as a weak antagonist of the NMDA receptor. O-Phosphono-L-homoserine can be used as a substrate for studies on amino acid metabolism of the aspartate family, a control for mechanism studies of PLP enzymes, and a reference for structure-activity relationship studies of NMDA receptor ligands.
    O-Phosphono-L-homoserine
  • HY-100714R
    DL-AP5 (Standard)
    		Antagonist
    DL-AP5 (Standard) is the analytical standard of DL-AP5. This product is intended for research and analytical applications. DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina.
    DL-AP5 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
iGluR Isoform Comparison

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