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Cat. No.: HY-100811R

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7-Chlorokynurenic acid (Standard)

Name: 7-Chlorokynurenic acid (Standard)
Brand: MedChemExpress
SKU: HY-100811R
Price: 115.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 7-CKA (Standard))

7-Chlorokynurenic acid (Standard) is the analytical standard of 7-Chlorokynurenic acid. This product is intended for research and analytical applications. 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 18000-24-3
Formula: C₁₀H₆ClNO₃
Molecular Weight:223.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

7-Chlorokynurenic acid (Standard) Chemical Structure

CAS No.: 18000-24-3

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 18000-24-3
Molecular Weight 223.61
Formula C₁₀H₆ClNO₃
SMILES

O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O
Synonyms

7-CKA (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. [Content Brief]

[2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196. [Content Brief]

[3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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7-Chlorokynurenic acid (Standard)