2. Vías de señalización
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Produits associés (10875):

Cat. No. Nom du produit Effet Pureté Chemical Structure
  • HY-N3807S
    Enniatin B1-13C34
    Enniatin B1-13C34 is the 13C-labeled Enniatin B1 (HY-N3807). Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.
    Enniatin B1-<sup>13</sup>C<sub>34</sub>
  • HY-18174S
    Prexasertib-d4
    Prexasertib-d4 (LY2606368-d4) is the deuterium labeled Prexasertib (HY-18174). Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.
    Prexasertib-d<sub>4</sub>
  • HY-117275S1
    Meclofenamic acid-13C6
    Meclofenamic acid-13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
    Meclofenamic acid-<sup>13</sup>C<sub>6</sub>
  • HY-B0144S
    Pitavastatin-d4 hemicalcium
    Pitavastatin-d4 (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].
    Pitavastatin-d<sub>4</sub> hemicalcium
  • HY-W009204S2
    Fmoc-Ala-OH-1-13C
    		98%
    Fmoc-Ala-OH-1-13C is the 13C labeled Fmoc-Ala-OH.
    Fmoc-Ala-OH-1-<sup>13</sup>C
  • HY-13609S3
    Deflazacort-d3-1
    Deflazacort-d3-1 is the deuterium labeled Deflazacort (HY-13609). Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant.
    Deflazacort-d<sub>3</sub>-1
  • HY-169984S
    Tyk2-IN-22-d3
    Tyk2-IN-22-d3 (Compound 1) is the deuterated analog of Tyk2-IN-22 (HY-168339). Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation.
    Tyk2-IN-22-d<sub>3</sub>
  • HY-146836S2
    (Rac)-16:0 PI(5)P-d5 diammonium
    		99.0%
    (Rac)-16:0 PI(5)P-d5 diammonium is deuterium labeled (Rac)-16:0 PI(5)P diammonium.
    (Rac)-16:0 PI(5)P-d<sub>5</sub> diammonium
  • HY-W010537S
    3-Chloropyridine-d4
    		99.3%
    3-Chloropyridine-d4 is the deuterium labeled 3-Chloropyridine.
    3-Chloropyridine-d<sub>4</sub>
  • HY-W739948
    Naltrexone-d3
    Naltrexone-d3 is a deuterated labeled Naltrexone (HY-76711). Naltrexone is an antagonist of Opioid receptor. Naltrexone inhibits cell proliferation in vivo. Naltrexone reduces tumor growth by interfering with cell signalling and modifying the immune system.
    Naltrexone-d<sub>3</sub>
  • HY-B0023S
    Azelnidipine-d7
    Azelnidipine-d7 is deuterium labeled Azelnidipine, which is a L-type calcium channel blocker.
    Azelnidipine-d<sub>7</sub>
  • HY-W745885
    2-(5-tert-Butyl-2-hydroxyphenyl)benzotriazole-d9
    2-(5-tert-Butyl-2-hydroxyphenyl)benzotriazole-d9 (2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-(tert-butyl)phenol-d9) is the deuterium labeled 2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-(tert-butyl)phenol (HY-W440436).
    2-(5-tert-Butyl-2-hydroxyphenyl)benzotriazole-d<sub>9</sub>
  • HY-W777774
    a-(Benzoylamino)benzeneacetamide-d10
    a-(Benzoylamino)benzeneacetamide-d10 is the deuterium labeled a-(Benzoylamino)benzeneacetamide.
    a-(Benzoylamino)benzeneacetamide-d<sub>10</sub>
  • HY-113301S
    Hexacosanoic acid-d4
    Hexacosanoic acid-d4 is the deuterium labeled Hexacosanoic acid (HY-113301). Hexacosanoic acid is a very long-chain fatty acid. Abnormally elevated levels of Hexacosanoic acid are closely associated with various diseases, such as X-linked adrenoleukodystrophy, adrenomyeloneuropathy, atherosclerosis, and dementia.
    Hexacosanoic acid-d<sub>4</sub>
  • HY-141629S
    N-Palmitoyl-D-sphingomyelin-d31
    		99%
    N-Palmitoyl-D-sphingomyelin-d31 is deuterium labeled N-Palmitoyl-D-sphingomyelin.
    N-Palmitoyl-D-sphingomyelin-d<sub>31</sub>
  • HY-W756434
    Desphenyl tenofovir alafenamide ammonium-d7
    Desphenyl tenofovir alafenamide ammonium-d7 is the deuterium labeled Desphenyl tenofovir alafenamide ammonium.
    Desphenyl tenofovir alafenamide ammonium-d<sub>7</sub>
  • HY-W778008
    Rac-Vigabatrin-13C,d2
    Rac-Vigabatrin-13C,d2 (Major) is the deuterium and 13C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.
    Rac-Vigabatrin-<sup>13</sup>C,d<sub>2</sub>
  • HY-W415090S
    Orange OT-d6
    Orange OT-d6 is a deuterated labeled Orange OT.
    Orange OT-d<sub>6</sub>
  • HY-W768684
    5b-Androst-16-en-3a-ol-d
    5b-Androst-16-en-3a-ol-d5 is the deuterium labeled 5β-Androst-16-en-3α-ol (HY-W779114).
    5b-Androst-16-en-3a-ol-d
  • HY-137215S1
    4-cis-Hydroxy Cilostazol-d5
    4-cis-Hydroxy Cilostazol-d5 is the deuterium labeled 4'-trans-Hydroxy Cilostazol[1].
    4-cis-Hydroxy Cilostazol-d<sub>5</sub>