2. Signaling Pathways
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Related Products (10876):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W587771S
    Mono-2-ethyl-5-carboxypentyl terephthalate-d4
    Mono-2-ethyl-5-carboxypentyl terephthalate-d4 (MECPTP-d4) is a deuterium labeled Mono-2-ethyl-5-carboxypentyl terephthalate.
    Mono-2-ethyl-5-carboxypentyl terephthalate-d<sub>4</sub>
  • HY-17367S5
    Atazanavir-d24
    Atazanavir-d24 (BMS-232632-d24) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death.
    Atazanavir-d<sub>24</sub>
  • HY-Y1840S
    3-Methoxyphenol-d3
    3-Methoxyphenol-d3 is deuterated labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is a phenolic compound that is biologically toxic. 3-Methoxyphenol is systemically absorbed, disrupts the function of the liver, kidneys, central nervous system, and redox processes, and increases levels of Hb, red blood cells, and white blood cells in the body.
    3-Methoxyphenol-d<sub>3</sub>
  • HY-W052253S
    2-(Piperazin-1-yl)pyrimidin-5-ol-d8 ditrifluoroacetate
    2-(Piperazin-1-yl)pyrimidin-5-ol-d8 (2-Piperazin-1-ylpyrimidin-5-ol-d8) diTFA is deuterium-labeled 2-(Piperazin-1-yl)pyrimidin-5-ol (HY-W052253).
    2-(Piperazin-1-yl)pyrimidin-5-ol-d<sub>8</sub> ditrifluoroacetate
  • HY-143811S
    N-Nitroso-DL-proline-d3
    N-Nitroso-DL-proline-d3 is the deuterium labeled N-Nitroso-DL-proline.
    N-Nitroso-DL-proline-d<sub>3</sub>
  • HY-W727525
    Donepezil-d7
    Donepezil-d7 (E2020-d7 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.
    Donepezil-d<sub>7</sub>
  • HY-W700069
    Gatifloxacin-d4
    Gatifloxacin-d4 (AM-1155-d4) is the deuterium labeled Gatifloxacin (HY-10581). Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50 = 13.8 μg/mL for S. aureus topoisomerase IV) and E.coli DNA gyrase (IC50 = 0.109 μg/mL). Gatifloxacin can be used for the study of bacterial conjunctivitis in vivo.
    Gatifloxacin-d<sub>4</sub>
  • HY-B0124S2
    Zonisamide-13C6
    Zonisamide-13C6 (AD 810-13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy.
    Zonisamide-<sup>13</sup>C<sub>6</sub>
  • HY-N8016S1
    Nonanal-d4
    Nonanal-d4 is deuterated labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
    Nonanal-d<sub>4</sub>
  • HY-W039433S1
    9-([1,1'-Biphenyl]-4-yl)-10-bromoanthracene-d17
    9-([1,1'-Biphenyl]-4-yl)-10-bromoanthracene-d17 is the deuterium labeled 9-([1,1'-Biphenyl]-4-yl)-10-bromoanthracene.
    9-([1,1'-Biphenyl]-4-yl)-10-bromoanthracene-d<sub>17</sub>
  • HY-118835S
    Zimeldine-d6
    Zimeldine-d6 is the deuterium labeled Zimeldine (HY-118835). Zimelidine is an orally active selective serotonin reuptake inhibitor. Zimelidine competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine is used for the study of depressive disorders and analgesic tolerance.
    Zimeldine-d<sub>6</sub>
  • HY-166917S
    1,3,6,8-Tetrachloro-dibenzofuran-13C12
    1,3,6,8-Tetrachloro-dibenzofuran-13C12 is 13C labeled 1,3,6,8-Tetrachlorodibenzofuran.
    1,3,6,8-Tetrachloro-dibenzofuran-<sup>13</sup>C<sub>12</sub>
  • HY-W013081S
    Fmoc-Gln(Trt)-OH-13C5,15N2
    Fmoc-Gln(Trt)-OH-13C5,15N2 is the 13C-labeled and 15N-labeled Fmoc-Gln(Trt)-OH (HY-W013081). Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc. Fmoc-Gln(Trt)-OH can be used in solid-phase peptide synthesis.
    Fmoc-Gln(Trt)-OH-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-Y0068S
    N-Acetyl-L-phenylalanine-13C2
    N-Acetyl-L-phenylalanine-13C2 (N-Acetylphenylalanine-13C2) is the 13C-labeled N-Acetyl-L-phenylalanine (HY-Y0068). N-Acetyl-L-phenylalanine (N-Acetylphenylalanine) is a principal acylamino acid. N-Acetyl-L-phenylalanine can be synthesized from L-phenylalanine and acetyl-CoA. N-Acetyl-L-phenylalanine can be used in kidney research.
    N-Acetyl-L-phenylalanine-<sup>13</sup>C<sub>2</sub>
  • HY-Y0787S1
    (E)-But-2-enal-13C
    (E)-But-2-enal-13C is the 13C-labeled (E)-But-2-enal.
    (E)-But-2-enal-<sup>13</sup>C
  • HY-141540S1
    Lactyl-CoA-d3
    Lactyl-CoA-d3 is the deuterium labeled Lactyl-CoA (HY-141540). Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers.
    Lactyl-CoA-d<sub>3</sub>
  • HY-W042337S
    3-Methyl-4-nitrophenol-d3
    3-Methyl-4-nitrophenol-d3 is the deuterium labeled 3-Methyl-4-nitrophenol (HY-W042337). 3-Methyl-4-nitrophenol, an environmental contaminant, is a well-known constituent of diesel exhaust particles and degradation products of insecticide fenitrothion. 3-Methyl-4-nitrophenol can induce nasal epithelial cell apoptosis and increase the permeability of the nasal epithelial barrier. 3-Methyl-4-nitrophenol is also toxic to the female reproductive system.
    3-Methyl-4-nitrophenol-d<sub>3</sub>
  • HY-P0036S
    Octreotide-d8 TFA
    Octreotide-d8 (SMS 201-995-d8) TFA is the deuterium labeled Octreotide TFA. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide-d<sub>8</sub> TFA
  • HY-N0176S6
    Dihydroartemisinin-d
    Dihydroartemisinin-d (Dihydroqinghaosu-d) is the deuterium labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
    Dihydroartemisinin-d
  • HY-122607S
    DPA-714-d10
    DPA-714-d10 is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
    DPA-714-d<sub>10</sub>