2. NF-κB
  3. IKK
  4. TBK1/IKKε-IN-1

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.

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TBK1/IKKε-IN-1

TBK1/IKKε-IN-1 Estructura química

No. CAS : 2058264-32-5

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TBK1/IKKε-IN-1 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

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Descripciòn

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.

IC50 & Target

TBK1

100 nM (IC50)

IKKε

100 nM (IC50)

In Vitro

IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TBK1/IKKε-IN-1 Related Antibodies
Peso molecular

498.53

Fòrmula

C28H26N4O5
No. CAS
SMILES

O=C(C1=CC(OC)=C(C2=CC3=NC=CC(C4=CC=C(OC5CCOCC5)C(C#N)=C4)=C3O2)N=C1)N(C)C
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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TBK1/IKKε-IN-1 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBK1/IKKε-IN-12058264-32-5IKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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Nombre del producto:
TBK1/IKKε-IN-1
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HY-U00457
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