2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Telratolimod

Telratolimod  (Synonyms: MEDI9197; 3M-052)

製品番号: HY-109104 純度: 98.44%
COA 取扱説明書 Technical Support

Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 1359993-59-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 588 在庫あり
Solution
10 mM * 1 mL in DMSO USD 588 在庫あり
Solid
1 mg $214 在庫あり
5 mg $450 在庫あり
10 mg $667 在庫あり
25 mg $1075 在庫あり
50 mg $1464 在庫あり
100 mg $1980 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Telratolimod:

Telratolimod 関連抗体

Top Publications Citing Use of Products

    Telratolimod purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 May 29;22(1):296.  [Abstract]

    UV-vis spectra of 3M-052 (Telratolimod), CM, UiO-66, NHWD-870, MCM@UN.

    Telratolimod purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 May 29;22(1):296.  [Abstract]

    Insertion of the immunostimulant (3M-052 (Telratolimod)) into the lipid bilayer of cancer cell membranes through the lipid tail of 18 C. (Dil labeled cell membrane, FITC labeled 3M-052).

    Telratolimod purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Feb;10(5):e2206001.  [Abstract]

    Telratolimod (0.2 mg/kg; intratumorally injection; single daily for 3 days) or Telratolimod loaded into the lipid droplets of adipocytes significantly inhibit growth of both original and distant tumor in vivo.

    Telratolimod purchased from MedChemExpress. Usage Cited in: ACS Cent Sci. 2022 Oct 26;8(10):1435-1446.  [Abstract]

    MC38 tumor-bearing mice were injected intratumorally with p(Man-TLR7-PDS), control TLR7/8 agonist 3M-052 (Telratolimod), or PBS. Six hours after injection, sera were collected and analyzed for proinflammatory cytokines, including IFNγ, IL-6, MCP-1, IFNβ and IL-27.

    Telratolimod purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 May 17;e146608.  [Abstract]

    Representative images of solutions containing micellar MEDI9197 before and after filtration. The numbers indicate molar ratio of MEDI9197 to DSPE-PEG-2000.

    Telratolimod purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 May 17;e146608.  [Abstract]

    Loading efficacy of MEDI9197 (Telratolimod, 30-300 μg) at various molar ratios of MEDI9197 to DSPE-PEG-2000 (n = 4).

    Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Telratolimod (MEDI9197) is a potent toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

    IC50 & Target

    TLR7

     

    TLR8

     

    体外実験

    Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Telratolimod 関連抗体
    体内実験

    Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    593.89

    分子式

    C36H59N5O2
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 62.5 mg/mL (105.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 50 mg/mL (84.19 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6838 mL 8.4191 mL 16.8381 mL
    5 mM 0.3368 mL 1.6838 mL 3.3676 mL
    10 mM 0.1684 mL 0.8419 mL 1.6838 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (3.50 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 98.85%

    COA (240 KB) LCMS (261 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 1.6838 mL 8.4191 mL 16.8381 mL 42.0953 mL
    5 mM 0.3368 mL 1.6838 mL 3.3676 mL 8.4191 mL
    10 mM 0.1684 mL 0.8419 mL 1.6838 mL 4.2095 mL
    15 mM 0.1123 mL 0.5613 mL 1.1225 mL 2.8064 mL
    20 mM 0.0842 mL 0.4210 mL 0.8419 mL 2.1048 mL
    25 mM 0.0674 mL 0.3368 mL 0.6735 mL 1.6838 mL
    30 mM 0.0561 mL 0.2806 mL 0.5613 mL 1.4032 mL
    40 mM 0.0421 mL 0.2105 mL 0.4210 mL 1.0524 mL
    50 mM 0.0337 mL 0.1684 mL 0.3368 mL 0.8419 mL
    60 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.7016 mL
    80 mM 0.0210 mL 0.1052 mL 0.2105 mL 0.5262 mL
    DMSO 100 mM 0.0168 mL 0.0842 mL 0.1684 mL 0.4210 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Telratolimod Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Telratolimod1359993-59-1MEDI9197 3M-052MEDI 9197MEDI-9197Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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    製品名:
    Telratolimod
    製品番号:
    HY-109104
    数量:
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