1. Cell Cycle/DNA Damage
  2. Topoisomerase

Teniposide (Synonyms: VM26)

Cat. No.: HY-13761 Purity: 99.84%
Data Sheet SDS Handling Instructions

Teniposide(VM-26) is a semisynthetic derivative of podophyllotoxin and are increasingly used in cancer medicine; causing breaks in DNA via an interaction with DNA topoisomerase II.

For research use only. We do not sell to patients.
Teniposide Chemical Structure

Teniposide Chemical Structure

CAS No. : 29767-20-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
25 mg USD 60 In-stock
50 mg USD 106 In-stock
100 mg USD 156 In-stock
200 mg USD 264 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Teniposide(VM-26) is a semisynthetic derivative of podophyllotoxin and are increasingly used in cancer medicine; causing breaks in DNA via an interaction with DNA topoisomerase II. IC50 value: Target: Topo II Teniposide is a phase-specific cytotoxic drug acting in the late S and early G2 phases of the cell cycle. It appears to act by causing breaks in DNA via an interaction with DNA topoisomerase II or by the formation of free radicals. The number of DNA-topoisomerase-II covalent complexes stabilized by VM-26 in WEHI-3B D+ cells was greatly increased when cells were exposed simultaneously to VM-26 and novobiocin for 1 hr, but not when cells were treated with m-AMSA and novobiocin for the same period of time.

Clinical Trial
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References
Molecular Weight

656.65

Formula

C₃₂H₃₂O₁₃S

CAS No.

29767-20-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.84%

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Teniposide
Cat. No.:
HY-13761
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