1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Bisoprolol hemifumarate

Bisoprolol hemifumarate 

Cat. No.: HY-B0076 Purity: 99.65%
Handling Instructions

Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

For research use only. We do not sell to patients.

Bisoprolol hemifumarate Chemical Structure

Bisoprolol hemifumarate Chemical Structure

CAS No. : 104344-23-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 75 In-stock
Estimated Time of Arrival: December 31
200 mg USD 131 In-stock
Estimated Time of Arrival: December 31
500 mg USD 264 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Bisoprolol hemifumarate:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Bisoprolol hemifumarate

    Bisoprolol hemifumarate purchased from MCE. Usage Cited in: Mol Neurobiol. 2019 Jan;56(1):367-377.

    Inhibitory effect of bisoprolol fumarate on PrPSc accumulation in N2a-FK cells. After the cells are incubated in medium mixed with each concentration of sample compound or water (negative control) for 48 h, the collected cell lysates are digested with proteinase K. Western blotting is then performed for quantification of the PrPSc level.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

    In Vivo

    Bisoprolol hemifumarate, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, Bisoprolol hemifumarate was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only Bisoprolol hemifumarate[1].
    Bisoprolol hemifumarate administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 bpm with placebo). Changes in HP were also significant with an increase in HP reaching 1004.5 msec at this controlled VT (compared to 860.3 msec with placebo)[2].
    Toxicity: Oral, mouse: LD50=100 mg/kg; Skin, rabbit: LD50=200 mg/kg; Skin, rat: LD50=500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    766.96

    Formula

    C18H31NO4.1/2C4H4O4

    CAS No.
    SMILES

    OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1.OC(/C=C/C(O)=O)=O.[1/2]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (65.19 mM)

    H2O : 20 mg/mL (26.08 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3038 mL 6.5192 mL 13.0385 mL
    5 mM 0.2608 mL 1.3038 mL 2.6077 mL
    10 mM 0.1304 mL 0.6519 mL 1.3038 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (130.38 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Bisoprolol hemifumarate
    Cat. No.:
    HY-B0076
    Quantity:
    MCE Japan Authorized Agent: