1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (±)-Bisoprolol hemifumarate

(±)-Bisoprolol hemifumarate (Synonyms: Bisoprolol hemifumarate salt)

Cat. No.: HY-B0076 Purity: 98.41%
Handling Instructions

(±)-Bisoprolol (hemifumarate) is a selective type β1 adrenergic receptor blocker.

For research use only. We do not sell to patients.

(±)-Bisoprolol hemifumarate Chemical Structure

(±)-Bisoprolol hemifumarate Chemical Structure

CAS No. : 104344-23-2

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10 mM * 1 mL in Water USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 82 In-stock
Estimated Time of Arrival: December 31
200 mg USD 119 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE (±)-Bisoprolol hemifumarate

    (±)-Bisoprolol hemifumarate purchased from MCE. Usage Cited in: Mol Neurobiol. 2019 Jan;56(1):367-377.

    Inhibitory effect of bisoprolol fumarate on PrPSc accumulation in N2a-FK cells. After the cells are incubated in medium mixed with each concentration of sample compound or water (negative control) for 48 h, the collected cell lysates are digested with proteinase K. Western blotting is then performed for quantification of the PrPSc level.
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    Description

    (±)-Bisoprolol (hemifumarate) is a selective type β1 adrenergic receptor blocker. Target: Adrenergic Receptor Approved: July 31, 1992 Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) [2]. Toxicity: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

    Molecular Weight

    766.96

    Formula

    C₄₀H₆₆N₂O₁₂

    CAS No.

    104344-23-2

    SMILES

    OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1.OC(CNC(C)C)COC2=CC=C(COCCOC(C)C)C=C2.OC(/C=C/C(O)=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (65.19 mM)

    H2O : 20 mg/mL (26.08 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

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    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3038 mL 6.5192 mL 13.0385 mL
    5 mM 0.2608 mL 1.3038 mL 2.6077 mL
    10 mM 0.1304 mL 0.6519 mL 1.3038 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Product name:
    (±)-Bisoprolol hemifumarate
    Cat. No.:
    HY-B0076
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