α-MSH (Synonyms: α-Melanocyte-Stimulating Hormone; α-メラノサイト刺激ホルモン)

Name: α-MSH
Brand: MedChemExpress
SKU: HY-P0252
Rating: 5.0 (23 reviews)

製品番号: HY-P0252 純度: 99.98%: Data Sheet SDS COA 取扱説明書
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α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

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CAS 番号 : 581-05-5

容量	価格（税別）	在庫状況	数量
1 mg	$66	在庫あり	Estimated Time of Arrival: December 31
5 mg	$198	在庫あり	Estimated Time of Arrival: December 31
10 mg	$343	在庫あり	Estimated Time of Arrival: December 31
25 mg	$739	在庫あり	Estimated Time of Arrival: December 31
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Based on 23 publication(s) in Google Scholar

Other Forms of α-MSH:

α-MSH TFA 在庫あり
α-MSH free acid お問い合わせ

顧客検証

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

Flow Cytometry

RT-PCR

: α-MSH purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979. [Abstract]; α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.

: α-MSH purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112. [Abstract]; α-MSH (0.1 μM; 48 h). Number of B16-F10 cells. Positive group: α-MSH.

: α-MSH purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740. [Abstract]; Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1 µM α-MSH (1 µM; 1 h) for 1 h. A representative result is shown from two independent experiments.

: α-MSH purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212. [Abstract]; α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).

: α-MSH purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501. [Abstract]; α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.

Melanocortin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

MC1R MC3R MC2R MC4R MC5R

生物活性
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target

MC4R

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.04 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay	[PMID: 32184956]
CHO	EC₅₀	0.0027 3 Compound: alpha-MSH	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	[PMID: 20329799]
HEK293	EC₅₀	0.14 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
CHO	EC₅₀	1.1 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	0.15 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
CHO	EC₅₀	1.9 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	0.22 1 Compound: alpha-MSH	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
CHO	IC₅₀	118 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	[PMID: 15982875]
CHO	EC₅₀	17 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	0.22 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	0.28 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
CHO	IC₅₀	19 1 Compound: alpha-MSH	Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	[PMID: 15582434]
CHO	IC₅₀	19 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	[PMID: 15982875]
HEK293	EC₅₀	0.3 1 Compound: alpha-MSH	Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
CHO	IC₅₀	19 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	[PMID: 15982875]
HEK293	EC₅₀	0.4 1 Compound: alpha-MSH	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
CHO	EC₅₀	2.2 1 Compound: alpha-MSH	Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay	[PMID: 20329799]
HEK293	EC₅₀	0.4 1 Compound: Alpha-MSH	Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells Agonistic activity evaluated at melanocortin 5 receptor (MC5R) of mouse HEK293 cells	[PMID: 14643357]
HEK293	IC₅₀	0.4 1 Compound: 14	Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4) Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	0.0009 3 Compound: alpha-MSH	Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay	[PMID: 20329799]
HEK293	EC₅₀	0.44 1 Compound: alpha-MSH	Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells	[PMID: 12477357]
HEK293	EC₅₀	0.04 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay	[PMID: 32184956]
HEK293	EC₅₀	0.5 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	0.14 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	0.51 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	0.15 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.52 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.22 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	0.22 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	0.55 1 Compound: alpha-MSH	Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells	[PMID: 12477357]
HEK293	EC₅₀	0.59 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.22 1 Compound: alpha-MSH	Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC5 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
HEK293	EC₅₀	0.28 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC1R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.6 1 Compound: Alpha-MSH	Agonistic activity evaluated at melanocortin 1 receptor (MC1R) of mouse HEK293 cells Agonistic activity evaluated at melanocortin 1 receptor (MC1R) of mouse HEK293 cells	[PMID: 14643357]
HEK293	EC₅₀	0.3 1 Compound: alpha-MSH	Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC1 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
HEK293	EC₅₀	0.65 1 Compound: alpha-MSH	Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
HEK293	EC₅₀	0.7 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	0.36 3 Compound: alpha-MSH	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	[PMID: 20329799]
HEK293	EC₅₀	0.4 1 Compound: alpha-MSH	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
HEK293	EC₅₀	0.7 1 Compound: 14	Effective concentration for intracellular cAMP accumulation in human melanocortin 1 receptor expressing HEK 293 cells; (N = 4) Effective concentration for intracellular cAMP accumulation in human melanocortin 1 receptor expressing HEK 293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	0.76 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.5 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	0.79 1 Compound: alpha-MSH	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	[PMID: 12477357]
HEK293	EC₅₀	0.51 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	0.8 1 Compound: Alpha-MSH	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	[PMID: 14643357]
HEK293	EC₅₀	0.52 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.59 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	0.9 1 Compound: alpha-MSH	Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay	[PMID: 20329799]
CHO	EC₅₀	1.1 1 Compound: alpha-MSH	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	[PMID: 15582434]
HEK293	EC₅₀	0.65 1 Compound: alpha-MSH	Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	[PMID: 24517312]
CHO	EC₅₀	1.1 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	0.7 1 Compound: alpha-MSH	Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC1R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	1.12 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	0.76 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	1.4 1 Compound: alpha-MSH	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R) In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	[PMID: 14552781]
HEK293	EC₅₀	1.12 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC5R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
CHO	EC₅₀	0.0027 3 Compound: alpha-MSH	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	[PMID: 20329799]
HEK293	EC₅₀	1.7 1 Compound: alpha-MSH	Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
HEK293	EC₅₀	1.6 1 Compound: alpha-MSH	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 1 receptor (hMC1R) In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 1 receptor (hMC1R)	[PMID: 14552781]
HEK293	EC₅₀	1.8 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	1.7 1 Compound: alpha-MSH	Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay Agonist activity at mouse MC4 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	[PMID: 26005535]
HEK293	EC₅₀	1.89 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	1.8 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	156 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
SAOS-2	EC₅₀	1.8 1 Compound: alpha-MSH	Activity at human MC1R by cAMP accumulation in SaoS2 cells Activity at human MC1R by cAMP accumulation in SaoS2 cells	[PMID: 16678415]
HEK293	EC₅₀	16.7 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	EC₅₀	1.89 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay Agonist activity at mouse MC4R expressed in HEK293 cells by beta-galactosidase assay	[PMID: 15615519]
HEK293	EC₅₀	18 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
CHO	EC₅₀	1.9 1 Compound: alpha-MSH	Effective concentration towards human melanocortin-4 receptor mediated cAMP accumulation in CHO cells Effective concentration towards human melanocortin-4 receptor mediated cAMP accumulation in CHO cells	[PMID: 15582434]
HEK293	EC₅₀	2 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
CHO	EC₅₀	1.9 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	2.14 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	2.56 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	2 1 Compound: alpha-MSH	Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC5R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	2.1 1 Compound: 14	Effective concentration for intracellular cAMP accumulation in human melanocortin 4 receptor expressing HEK 293 cells; (N = 4) Effective concentration for intracellular cAMP accumulation in human melanocortin 4 receptor expressing HEK 293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	2.6 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	2.14 1 Compound: alpha-MSH	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	2.9 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
CHO	EC₅₀	2.2 1 Compound: alpha-MSH	Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay	[PMID: 20329799]
HEK293	EC₅₀	2.9 1 Compound: alpha-MSH	Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	2.56 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay Agonist activity at mouse MC4R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	[PMID: 18271518]
HEK293	EC₅₀	21 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	2.6 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	21 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	24.4 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay	[PMID: 28972753]
HEK293	EC₅₀	2.9 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells by AlphaScreen cAMP assay Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	[PMID: 26433448]
HEK293	EC₅₀	2.9 1 Compound: alpha-MSH	Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	27 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	3.7 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	3.7 1 Compound: alpha-MSH	Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	[PMID: 32184956]
HEK293	EC₅₀	4 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	35.3 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	IC₅₀	5 1 Compound: 14	Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4) Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	4 1 Compound: alpha-MSH	Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	[PMID: 26959173]
HEK293	EC₅₀	5.37 1 Compound: alpha-MSH	Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells	[PMID: 12477357]
HEK293	EC₅₀	7.1 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	89 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	5.4 1 Compound: Alpha-MSH	Agonistic activity evaluated at melanocortin 4 receptor (MC4R) of mouse HEK293 cells Agonistic activity evaluated at melanocortin 4 receptor (MC4R) of mouse HEK293 cells	[PMID: 14643357]
HEK293	EC₅₀	6.1 1 Compound: alpha-MSH	In vitro cAMP accumulation in HEK cells transfected with human melanocortin receptor-4 (hMC4R) In vitro cAMP accumulation in HEK cells transfected with human melanocortin receptor-4 (hMC4R)	[PMID: 14552781]
HEK293	EC₅₀	9.2 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEK293	EC₅₀	6.7 1 Compound: 14	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4) Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	[PMID: 15771429]
SAOS-2	EC₅₀	1.8 1 Compound: alpha-MSH	Activity at human MC1R by cAMP accumulation in SaoS2 cells Activity at human MC1R by cAMP accumulation in SaoS2 cells	[PMID: 16678415]
HEK293	EC₅₀	7.1 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
SAOS-2	EC₅₀	72.9 1 Compound: alpha-MSH	Activity at human MC4R by cAMP accumulation in SaoS2 cells Activity at human MC4R by cAMP accumulation in SaoS2 cells	[PMID: 16678415]
HEK293	EC₅₀	0.36 3 Compound: alpha-MSH	Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay	[PMID: 20329799]
HEK293	EC₅₀	8.1 1 Compound: 14	Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4) Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	0.32 3 Compound: alpha-MSH	Compound was evaluated for its agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells Compound was evaluated for its agonist activity on mouse melanocortin 1 receptor (mMC1R) stably expressed in HEK cells	[PMID: 12781199]
HEK293	EC₅₀	1.21 3 Compound: alpha-MSH	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	[PMID: 12781199]
HEK293	EC₅₀	9.2 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
HEL	EC₅₀	2.47 3 Compound: alpha-MSH	Compound was evaluated for its agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells Compound was evaluated for its agonist activity on mouse melanocortin 4 receptor (mMC4R) stably expressed in HEL cells	[PMID: 12781199]
HEL	EC₅₀	1.49 3 Compound: alpha-MSH	Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells Compound was evaluated for its agonist activity on mouse melanocortin 5 receptor (mMC5R) stably expressed in HEL cells	[PMID: 12781199]
HEK293	EC₅₀	16.7 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
CHO	EC₅₀	17 1 Compound: alpha-MSH	Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells Effective concentration towards human melanocortin-5 receptor mediated cAMP accumulation in CHO cells	[PMID: 15582434]
CHO	EC₅₀	17 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells) Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	[PMID: 15982875]
HEK293	EC₅₀	18 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	IC₅₀	18 1 Compound: 14	Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4 Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4	[PMID: 15771429]
CHO	IC₅₀	19 1 Compound: alpha-MSH	Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand Concentration for 50% inhibition of human melanocortin-4 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	[PMID: 15582434]
CHO	IC₅₀	19 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	[PMID: 15982875]
CHO	IC₅₀	19 1 Compound: alpha-MSH	Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells	[PMID: 15808454]
HEK293	EC₅₀	21 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	24.4 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic complementation based assay	[PMID: 28972753]
HEK293	EC₅₀	27 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
HEK293	EC₅₀	29 1 Compound: alpha-MSH	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R) In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)	[PMID: 14552781]
HEK293	IC₅₀	30 1 Compound: 14	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4) Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	[PMID: 15771429]
HEK293	EC₅₀	35.3 1 Compound: alpha-MSH	Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	[PMID: 28972753]
SAOS-2	EC₅₀	72.9 1 Compound: alpha-MSH	Activity at human MC4R by cAMP accumulation in SaoS2 cells Activity at human MC4R by cAMP accumulation in SaoS2 cells	[PMID: 16678415]
HEK293	EC₅₀	89 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]
CHO	IC₅₀	118 1 Compound: Alpha-MSH	Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	[PMID: 15982875]
HEK293	EC₅₀	156 1 Compound: alpha-MSH	Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation	[PMID: 16451057]

体外実験

α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	IL-10–deficient mice^[3]
Dosage:	50 µg/0.2 ml saline
Administration:	I.p.
Result:	Given systemically effectively modulated inflammatory reactions.

分子量

1664.88

分子式

C₇₇H₁₀₉N₂₁O₁₉S

CAS 番号

581-05-5

Appearance

Solid

Color

White to off-white

Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Sequence Shortening

Ac-SYSMEHFRWGKPV-NH2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (60.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 12.5 mg/mL (7.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6006 mL	3.0032 mL	6.0064 mL
5 mM	0.1201 mL	0.6006 mL	1.2013 mL
10 mM	0.0601 mL	0.3003 mL	0.6006 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.98%

Select Batch:

データシート (275 KB) SDS (252 KB)

COA (251 KB) RP-HPLC (290 KB) MS (205 KB) Elemental Analysis Report (110 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. [Content Brief]

[2]. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. [Content Brief]

[3]. Lipton JM, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999;885:173-182. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.6006 mL	3.0032 mL	6.0064 mL	15.0161 mL
H₂O / DMSO	5 mM	0.1201 mL	0.6006 mL	1.2013 mL	3.0032 mL
DMSO	10 mM	0.0601 mL	0.3003 mL	0.6006 mL	1.5016 mL
	15 mM	0.0400 mL	0.2002 mL	0.4004 mL	1.0011 mL
	20 mM	0.0300 mL	0.1502 mL	0.3003 mL	0.7508 mL
	25 mM	0.0240 mL	0.1201 mL	0.2403 mL	0.6006 mL
	30 mM	0.0200 mL	0.1001 mL	0.2002 mL	0.5005 mL
	40 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.3754 mL
	50 mM	0.0120 mL	0.0601 mL	0.1201 mL	0.3003 mL
	60 mM	0.0100 mL	0.0501 mL	0.1001 mL	0.2503 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

α-MSH Related Classifications

Neurological Disease Metabolic Disease Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-MSH581-05-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC Receptoralpha-melanocyte-stimulatinghormoneendogenousanti-inflammatoryneuroimmunomodulatorypeptideinflammationInhibitorinhibitorinhibit

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α-MSH (Synonyms: α-Melanocyte-Stimulating Hormone; α-メラノサイト刺激ホルモン)

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顧客検証

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α-MSH (Synonyms: α-Melanocyte-Stimulating Hormone; α-メラノサイト刺激ホルモン)

カスタマーレビュー

Other Forms of α-MSH:

α-MSH 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Melanocortin Receptor アイソフォーム固有の製品をすべて表示:

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α-MSH 関連抗体

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Complete Stock Solution Preparation Table

α-MSH Related Classifications

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