2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. α-MSH

α-MSH  (Synonyms: α-Melanocyte-Stimulating Hormone; α-メラノサイト刺激ホルモン)

製品番号: HY-P0252 純度: 99.98%
COA 取扱説明書 Technical Support

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

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カスタムペプチド

CAS 番号 : 581-05-5

容量 価格（税別） 在庫状況 数量
1 mg $66 在庫あり
5 mg $198 在庫あり
10 mg $343 在庫あり
25 mg $739 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 23 publication(s) in Google Scholar

Other Forms of α-MSH:

α-MSH 関連抗体

Top Publications Citing Use of Products

    α-MSH purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979.  [Abstract]

    α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.

    α-MSH purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112.  [Abstract]

    α-MSH (0.1  μM; 48  h). Number of B16-F10 cells. Positive group: α-MSH.

    α-MSH purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740.  [Abstract]

    Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1  µM α-MSH (1  µM; 1  h) for 1  h. A representative result is shown from two independent experiments.

    α-MSH purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212.  [Abstract]

    α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).

    α-MSH purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501.  [Abstract]

    α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.

    Melanocortin Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    MC1R MC3R MC2R MC4R MC5R

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

    IC50 & Target

    MC4R

     

    体外実験

    α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    α-MSH 関連抗体
    体内実験

    α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: IL-10–deficient mice[3]
    Dosage: 50 µg/0.2 ml saline
    Administration: I.p.
    Result: Given systemically effectively modulated inflammatory reactions.
    分子量

    1664.88

    分子式

    C77H109N21O19S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
    Sequence Shortening

    Ac-SYSMEHFRWGKPV-NH2
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    polypeptide, sealed storage, away from moisture and light, under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (60.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 12.5 mg/mL (7.51 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6006 mL 3.0032 mL 6.0064 mL
    5 mM 0.1201 mL 0.6006 mL 1.2013 mL
    10 mM 0.0601 mL 0.3003 mL 0.6006 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.98%

    COA (251 KB) RP-HPLC (290 KB) MS (205 KB) Elemental Analysis Report (110 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.6006 mL 3.0032 mL 6.0064 mL 15.0161 mL
    5 mM 0.1201 mL 0.6006 mL 1.2013 mL 3.0032 mL
    DMSO 10 mM 0.0601 mL 0.3003 mL 0.6006 mL 1.5016 mL
    15 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0011 mL
    20 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
    25 mM 0.0240 mL 0.1201 mL 0.2403 mL 0.6006 mL
    30 mM 0.0200 mL 0.1001 mL 0.2002 mL 0.5005 mL
    40 mM 0.0150 mL 0.0751 mL 0.1502 mL 0.3754 mL
    50 mM 0.0120 mL 0.0601 mL 0.1201 mL 0.3003 mL
    60 mM 0.0100 mL 0.0501 mL 0.1001 mL 0.2503 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    α-MSH Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    α-MSH581-05-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC Receptoralpha-melanocyte-stimulatinghormoneendogenousanti-inflammatoryneuroimmunomodulatorypeptideinflammationInhibitorinhibitorinhibit

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    製品名:
    α-MSH
    製品番号:
    HY-P0252
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