2. GPCR/G Protein
  3. Adenosine Receptor
  4. A2A/A3 agonist-1

A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases.

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A2A/A3 agonist-1

A2A/A3 agonist-1 構造式

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A2A/A3 agonist-1 関連抗体

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Adenosine Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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製品説明

A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases[1].

体外実験

A2A/A3 agonist-1 (10-50 nM; 24 h) exhibits potent inhibitory effects on IL-12/IL-23p40 and IL-6 in LPS (HY-D1056)-stimulated bone marrow-derived dendritic cells (BMDCs)1.
A2A/A3 agonist-1 (1 μM; 0-60 min) shows favorable metabolic stability in human liver microsomes and plasma with no meaningful hERG inhibition1.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A2A/A3 agonist-1 関連抗体

ELISA Assay[1]

Cell Line: LPS treated BMDCs
Concentration: 10,50 nM
Incubation Time: 24h
Result: Inhibited the production of IL-12/IL-23p40 and IL-6.
分子量

404.49

分子式

C18H24N6O3S
SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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A2A/A3 agonist-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A2A/A3 agonist-1Adenosine ReceptorP1 receptorA3 adenosine receptor agonistAnti-inflammatoryreceptor dual agonistA2A adenosine receptor agonistBMDCsInhibitorinhibitorinhibit

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製品名:
A2A/A3 agonist-1
製品番号:
HY-179681
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