Ac5GalNTGc epimer

Cat. No.: HY-160109A Pureza: 98.39%: Ficha de datos
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Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research.

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Ac5GalNTGc epimer Estructura química

No. CAS : 1334320-77-2

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 Customer Validation

Other Forms of Ac5GalNTGc epimer:

Ac5GalNTGc In-stock

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Mucin:

Ver todas las isoformas

MUC5AC MUC1

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Peso molecular

463.46

Fòrmula

C₁₈H₂₅NO₁₁S

No. CAS

1334320-77-2

Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@@H]1[C@H](C(O[C@@H]([C@@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CSC(C)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : ≥ 50 mg/mL (107.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1577 mL	10.7884 mL	21.5768 mL
5 mM	0.4315 mL	2.1577 mL	4.3154 mL
10 mM	0.2158 mL	1.0788 mL	2.1577 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.39%

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Ficha de datos (276 KB) SDS (251 KB)

COA (254 KB) HNMR (162 KB) RP-HPLC (169 KB) LCMS (382 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Agarwal K, et al. Inhibition of mucin-type O-glycosylation through metabolic processing and incorporation of N-thioglycolyl-D-galactosamine peracetate (Ac5GalNTGc). J Am Chem Soc. 2013 Sep 25;135(38):14189-97. [Content Brief]

[2]. Wang SS, et al. Efficient inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc. Cell Chem Biol. 2021 May 20;28(5):699-710.e5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1577 mL	10.7884 mL	21.5768 mL	53.9421 mL
	5 mM	0.4315 mL	2.1577 mL	4.3154 mL	10.7884 mL
	10 mM	0.2158 mL	1.0788 mL	2.1577 mL	5.3942 mL
	15 mM	0.1438 mL	0.7192 mL	1.4385 mL	3.5961 mL
	20 mM	0.1079 mL	0.5394 mL	1.0788 mL	2.6971 mL
	25 mM	0.0863 mL	0.4315 mL	0.8631 mL	2.1577 mL
	30 mM	0.0719 mL	0.3596 mL	0.7192 mL	1.7981 mL
	40 mM	0.0539 mL	0.2697 mL	0.5394 mL	1.3486 mL
	50 mM	0.0432 mL	0.2158 mL	0.4315 mL	1.0788 mL
	60 mM	0.0360 mL	0.1798 mL	0.3596 mL	0.8990 mL
	80 mM	0.0270 mL	0.1349 mL	0.2697 mL	0.6743 mL
	100 mM	0.0216 mL	0.1079 mL	0.2158 mL	0.5394 mL