1334320-77-2
Chemical Structure
Ac5GalNTGc epimer
- CAS No.: 1334320-77-2
- Formula:C18H25NO11S
- Molecular Weight:463.46
InChIKey: QIAVTYOXBOYXHI-SRKZOOFXSA-N
SMILES: CC(O[C@@H]1[C@H](C(O[C@@H]([C@@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CSC(C)=O)=O)=O
Biological Activity: Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac5GalNTGc epimer | 98.39% | Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research. | ||||||||||||||||||||
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References
- [1]. Agarwal K, et al. Inhibition of mucin-type O-glycosylation through metabolic processing and incorporation of N-thioglycolyl-D-galactosamine peracetate (Ac5GalNTGc). J Am Chem Soc. 2013 Sep 25;135(38):14189-97. [Content Brief]
- [2]. Wang SS, et al. Efficient inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc. Cell Chem Biol. 2021 May 20;28(5):699-710.e5. [Content Brief]
