アデフォビル (Synonyms: Adefovir)

Name: Adefovir
Brand: MedChemExpress
SKU: HY-B1826
Rating: 5.0 (2 reviews)

製品番号: HY-B1826 純度: 99.55%: Data Sheet SDS COA 取扱説明書
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Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC₅₀ of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

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アデフォビル 構造式

CAS 番号 : 106941-25-7

容量	価格（税別）	在庫状況	数量
25 mg	$50	在庫あり	Estimated Time of Arrival: December 31
50 mg	$80	在庫あり	Estimated Time of Arrival: December 31
100 mg	$120	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Adefovir:

Adefovir-d₄ 在庫あり

顧客検証

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生物活性
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製品説明

IC₅₀ & Target

HBV^[1]^[2]^[3];
DNA polymerase^[1]^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
C-33-A	IC₅₀	7.8 3 Compound: 1, PMEA	Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis	[PMID: 24686012]
C3H/3T3	EC₅₀	0.53 3 Compound: PMEA, Adefovir	Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days	[PMID: 18556209]
C3H/3T3	EC₅₀	2.1 3 Compound: PMEA	Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis	[PMID: 21429755]
BSC-1	CC₅₀	210.1 3 Compound: PMEA	Cytotoxicity against african green monkey BSC1 cells Cytotoxicity against african green monkey BSC1 cells	[PMID: 17420214]
C8166	EC₅₀	1.7 3 Compound: PMEA	Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells	10.1016/0960-894X(95)00208-B
BSC-1	EC₅₀	125.9 3 Compound: PMEA	Antiviral activity against Simian virus 40 PML2 DAR in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against Simian virus 40 PML2 DAR in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 17420214]
C8166	EC₅₀	7 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
C-33-A	IC₅₀	7.8 3 Compound: 1, PMEA	Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis	[PMID: 24686012]
BSC-1	EC₅₀	157.7 3 Compound: PMEA	Antiviral activity against Simian virus 40 A2895 in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against Simian virus 40 A2895 in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 17420214]
CCRF-CEM	CC₅₀	≥ 250 3 Compound: PMEA	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis	[PMID: 21429755]
C3H/3T3	EC₅₀	2.1 3 Compound: PMEA	Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis	[PMID: 21429755]
BSC-1	EC₅₀	168 3 Compound: PMEA	Antiviral activity against Simian virus 40 PML1 EK in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against Simian virus 40 PML1 EK in african green monkey BSC1 cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 17420214]
CCRF-CEM	EC₅₀	10.4 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
C-33-A	IC₅₀	7.8 3 Compound: 1, PMEA	Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis	[PMID: 24686012]
C3H/3T3	EC₅₀	0.25 6 Compound: PMEA (adefovir)	Inhibition of moloney sarcoma virus (MSV) induced cytopathicity in C3H/3T3 embryo fibroblast cells Inhibition of moloney sarcoma virus (MSV) induced cytopathicity in C3H/3T3 embryo fibroblast cells	[PMID: 11960502]
C3H/3T3	EC₅₀	0.53 3 Compound: PMEA, Adefovir	Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days	[PMID: 18556209]
CCRF-CEM	CC₅₀	164 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
C3H/3T3	EC₅₀	0.25 6 Compound: PMEA (adefovir)	Inhibition of moloney sarcoma virus (MSV) induced cytopathicity in C3H/3T3 embryo fibroblast cells Inhibition of moloney sarcoma virus (MSV) induced cytopathicity in C3H/3T3 embryo fibroblast cells	[PMID: 11960502]
CCRF-CEM	EC₅₀	18 3 Compound: PMEA	In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay	[PMID: 1323678]
C8166	EC₅₀	7 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
C3H/3T3	EC₅₀	0.53 3 Compound: PMEA, Adefovir	Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days	[PMID: 18556209]
CCRF-CEM	IC₅₀	24 3 Compound: 1, PMEA	Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
C3H/3T3	EC₅₀	2.1 3 Compound: PMEA	Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis	[PMID: 21429755]
C8166	EC₅₀	1.5 3 Compound: PMEA	Compound was evaluated for the inhibition of p24 viral antigen production in C-8166 cells. Compound was evaluated for the inhibition of p24 viral antigen production in C-8166 cells.	10.1016/0960-894X(95)00585-H
C8166	EC₅₀	1.7 3 Compound: PMEA	Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells	10.1016/0960-894X(95)00208-B
CCRF-CEM	EC₅₀	5.5 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
C8166	EC₅₀	1.5 3 Compound: PMEA	Compound was evaluated for the inhibition of p24 viral antigen production in C-8166 cells. Compound was evaluated for the inhibition of p24 viral antigen production in C-8166 cells.	10.1016/0960-894X(95)00585-H
CCRF-CEM	EC₅₀	7 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy	[PMID: 21745746]
C8166	EC₅₀	1.7 3 Compound: PMEA	Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells	10.1016/0960-894X(95)00208-B
CCRF-CEM	CC₅₀	0.056 92 Compound: PMEA	Cytotoxicity against CEM (human lymphoblastic leukemia) cells in vitro. Cytotoxicity against CEM (human lymphoblastic leukemia) cells in vitro.	[PMID: 14584956]
CCRF-CEM	CC₅₀	50 3 Compound: 1, PMEA	Cytotoxicity against CEM/O cells Cytotoxicity against CEM/O cells	[PMID: 16335932]
CCRF-CEM	EC₅₀	7 3 Compound: PMEA	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
C8166	EC₅₀	7 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis	[PMID: 21745746]
CCRF-CEM	CC₅₀	85 3 Compound: PMEA, Adefovir	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 21803462]
CCRF-CEM	CC₅₀	0.056 2 Compound: PMEA	Cytotoxicity against CEM (human lymphoblastic leukemia) cells in vitro. Cytotoxicity against CEM (human lymphoblastic leukemia) cells in vitro.	[PMID: 14584956]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA	Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
CCRF-CEM	CC₅₀	164 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
CCRF-CEM	CC₅₀	>= 50 3 Compound: 1, PMEA	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 24686012]
CCRF-CEM	EC₅₀	8.2 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
CCRF-CEM	CC₅₀	50 3 Compound: 1, PMEA	Cytotoxicity against CEM/O cells Cytotoxicity against CEM/O cells	[PMID: 16335932]
CCRF-CEM	CC₅₀	164 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
CCRF-CEM	EC₅₀	8.4 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
CCRF-CEM	CC₅₀	69 3 Compound: 2	In vitro cytotoxic concentration against CEM cells In vitro cytotoxic concentration against CEM cells	[PMID: 11327587]
CCRF-CEM	CC₅₀	>= 250 3 Compound: PMEA	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis	[PMID: 21429755]
CCRF-CEM	EC₅₀	8.6 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
CCRF-CEM	CC₅₀	85 3 Compound: PMEA, Adefovir	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 21803462]
CCRF-CEM	CC₅₀	69 3 Compound: 2	In vitro cytotoxic concentration against CEM cells In vitro cytotoxic concentration against CEM cells	[PMID: 11327587]
CHO	CC₅₀	≥ 2000 3 Compound: Adefovir	Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CCRF-CEM	EC₅₀	5.5 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
CCRF-CEM	CC₅₀	>= 250 3 Compound: PMEA	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis	[PMID: 21429755]
CHO	CC₅₀	1.4 3 Compound: Adefovir	Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CCRF-CEM	EC₅₀	10.4 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
CCRF-CEM	CC₅₀	>= 50 3 Compound: 1, PMEA	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 24686012]
CHO	CC₅₀	3 3 Compound: Adefovir	Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CCRF-CEM	EC₅₀	8.6 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
CCRF-CEM	EC₅₀	0.0033 2 Compound: PMEA	Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells. Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells.	[PMID: 14584956]
H9	CC₅₀	> 30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay	[PMID: 21803462]
CCRF-CEM	EC₅₀	0.0066 2 Compound: PMEA	Antiviral activity against HIV-2 (ROD) in CEM (human leukemia) cells. Antiviral activity against HIV-2 (ROD) in CEM (human leukemia) cells.	[PMID: 14584956]
CCRF-CEM	EC₅₀	0.0033 92 Compound: PMEA	Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells. Antiviral activity against HIV-1 (IIIB) in CEM (human leukemia) cells.	[PMID: 14584956]
H9	EC₅₀	1.1 3 Compound: PMEA, Adefovir	Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
CCRF-CEM	EC₅₀	1.8 6 Compound: PMEA (adefovir)	Inhibition of Human immunodeficiency virus (HIV) -1 III B strain induced cytopathicity in CEM cell line Inhibition of Human immunodeficiency virus (HIV) -1 III B strain induced cytopathicity in CEM cell line	[PMID: 11960502]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA	Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
CCRF-CEM	EC₅₀	0.0066 92 Compound: PMEA	Antiviral activity against HIV-2 (ROD) in CEM (human leukemia) cells. Antiviral activity against HIV-2 (ROD) in CEM (human leukemia) cells.	[PMID: 14584956]
H9	EC₅₀	7.9 3 Compound: PMEA, Adefovir	Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
CCRF-CEM	EC₅₀	10 3 Compound: 2	In vitro antiviral activity against HIV-2 in CEM cells In vitro antiviral activity against HIV-2 in CEM cells	[PMID: 11327587]
HEK-293T	CC₅₀	> 100 3 Compound: PMEA	Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method	[PMID: 17470654]
CCRF-CEM	EC₅₀	7 3 Compound: PMEA	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
CCRF-CEM	EC₅₀	10.4 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
CCRF-CEM	EC₅₀	8.4 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
HEL 299	EC₅₀	> 183 3 Compound: 3a, PMEA	Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
CCRF-CEM	EC₅₀	18 3 Compound: PMEA	In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay	[PMID: 1323678]
HEL 299	EC₅₀	> 183 3 Compound: 3a, PMEA	Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
CCRF-CEM	EC₅₀	2.5 6 Compound: PMEA (adefovir)	Inhibition of Human immunodeficiency virus (HIV)-2 ROD strain induced cytopathicity in CEM cell line Inhibition of Human immunodeficiency virus (HIV)-2 ROD strain induced cytopathicity in CEM cell line	[PMID: 11960502]
CCRF-CEM	EC₅₀	7 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy	[PMID: 21745746]
CCRF-CEM	EC₅₀	8.2 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
HEL 299	CC₅₀	211 3 Compound: 3a, PMEA	Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis	[PMID: 17893157]
CCRF-CEM	EC₅₀	5.5 3 Compound: PMEA, Adefovir	Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis	[PMID: 21803462]
HeLa	CC₅₀	> 250 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis	[PMID: 21745746]
CCRF-CEM	EC₅₀	7 3 Compound: 2	In vitro antiviral activity against HIV-1 in CEM cells In vitro antiviral activity against HIV-1 in CEM cells	[PMID: 11327587]
HeLa	IC₅₀	181 3 Compound: 1, PMEA	Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
CCRF-CEM	EC₅₀	18 3 Compound: PMEA	In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay	[PMID: 1323678]
CCRF-CEM	EC₅₀	7 3 Compound: PMEA	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
HepG2	IC₅₀	42.1 3 Compound: PMEA, 1	Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay	[PMID: 17888662]
CCRF-CEM	EC₅₀	7 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy	[PMID: 21745746]
CCRF-CEM	EC₅₀	7 3 Compound: 2	In vitro antiviral activity against HIV-1 in CEM cells In vitro antiviral activity against HIV-1 in CEM cells	[PMID: 11327587]
HepG2 2.2.15	IC₅₀	0.517 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR	[PMID: 20000776]
CCRF-CEM	EC₅₀	10 3 Compound: 2	In vitro antiviral activity against HIV-2 in CEM cells In vitro antiviral activity against HIV-2 in CEM cells	[PMID: 11327587]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA	Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis	[PMID: 21429755]
HepG2 2.2.15	IC₅₀	0.517 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method	[PMID: 23353737]
CCRF-CEM	EC₅₀	1.8 6 Compound: PMEA (adefovir)	Inhibition of Human immunodeficiency virus (HIV) -1 III B strain induced cytopathicity in CEM cell line Inhibition of Human immunodeficiency virus (HIV) -1 III B strain induced cytopathicity in CEM cell line	[PMID: 11960502]
CCRF-CEM	EC₅₀	7.4 3 Compound: PMEA, adefovir	Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis	[PMID: 21745746]
HepG2 2.2.15	EC₅₀	1.3 3 Compound: Adefovir	Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method	[PMID: 21930377]
CCRF-CEM	EC₅₀	8.2 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
CCRF-CEM	EC₅₀	2.5 6 Compound: PMEA (adefovir)	Inhibition of Human immunodeficiency virus (HIV)-2 ROD strain induced cytopathicity in CEM cell line Inhibition of Human immunodeficiency virus (HIV)-2 ROD strain induced cytopathicity in CEM cell line	[PMID: 11960502]
HepG2 2.2.15	EC₅₀	1.6 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
CCRF-CEM	IC₅₀	285 6 Compound: 4	Cellular toxic effect was determined in CEM cells Cellular toxic effect was determined in CEM cells	[PMID: 11606136]
CCRF-CEM	EC₅₀	8.4 3 Compound: 1, PMEA	Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis	[PMID: 24686012]
HepG2 2.2.15	EC₅₀	1.9 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
CCRF-CEM	EC₅₀	8.6 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy	[PMID: 21565516]
CCRF-CEM	IC₅₀	24 3 Compound: 1, PMEA	Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
HepG2 2.2.15	EC₅₀	2.1 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb	[PMID: 21930377]
CCRF-CEM	IC₅₀	2 6 Compound: 4	Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay	[PMID: 11606136]
CCRF-CEM	IC₅₀	24 3 Compound: 1, PMEA	Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
HepG2 2.2.15	CC₅₀	200 3 Compound: Adefovir	Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay	[PMID: 28082068]
CCRF-CEM	IC₅₀	285 6 Compound: 4	Cellular toxic effect was determined in CEM cells Cellular toxic effect was determined in CEM cells	[PMID: 11606136]
HepG2 2.2.15	IC₅₀	215 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA	[PMID: 25650312]
CCRF-CEM	IC₅₀	2 6 Compound: 4	Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay Inhibition of antiviral activity against moloney murine sarcoma virus(MSV)in CEM cells in cell protection assay	[PMID: 11606136]
HepG2 2.2.15	IC₅₀	257 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA	[PMID: 25650312]
CHO	CC₅₀	>= 2 2 Compound: Adefovir	Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	IC₅₀	286 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA	[PMID: 23353737]
CHO	CC₅₀	3 3 Compound: Adefovir	Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	IC₅₀	286 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA	[PMID: 20000776]
CHO	CC₅₀	1.4 3 Compound: Adefovir	Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	IC₅₀	305 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA	[PMID: 23353737]
CHO	IC₅₀	28 3 Compound: Adefovir	TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells	[PMID: 10929807]
CEM-SS	CC₅₀	> 10 3 Compound: 1	Compound was tested for antiviral activity against the CEM-SS cell lines infected with HIV-1. Compound was tested for antiviral activity against the CEM-SS cell lines infected with HIV-1.	[PMID: 8960556]
HepG2 2.2.15	IC₅₀	305 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA	[PMID: 20000776]
CEM-SS	EC₅₀	0.42 3 Compound: 1	Compound was tested for antiviral activity against the CEM-SS cell lines infected with HIV-1. Compound was tested for antiviral activity against the CEM-SS cell lines infected with HIV-1.	[PMID: 8960556]
HepG2 2.2.15	CC₅₀	490 3 Compound: Adefovir	Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay	[PMID: 25650312]
HepG2 2.2.15	EC₅₀	5.5 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
H9	CC₅₀	>30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay	[PMID: 21803462]
CHO	CC₅₀	1.4 3 Compound: Adefovir	Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	CC₅₀	540 3 Compound: Adefovir	Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay	[PMID: 23353737]
H9	EC₅₀	1.1 3 Compound: PMEA, Adefovir	Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
CHO	CC₅₀	3 3 Compound: Adefovir	Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	CC₅₀	57 3 Compound: adefovir	Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay	[PMID: 17499889]
H9	EC₅₀	7.9 3 Compound: PMEA, Adefovir	Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
CHO	CC₅₀	>= 2000 3 Compound: Adefovir	Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
HepG2 2.2.15	EC₅₀	7.8 3 Compound: Adefovir	Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth	[PMID: 21930377]
H9	EC₅₀	17.76 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade A isolate 4113 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade A isolate 4113 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
CHO	IC₅₀	28 3 Compound: Adefovir	TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells	[PMID: 10929807]
Huh-7	EC₅₀	1.3 3 Compound: adefovir	Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
H9	EC₅₀	0.32 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade A/E isolate 2165 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade A/E isolate 2165 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
Huh-7	EC₅₀	1.5 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
H9	EC₅₀	1.85 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 1722 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 1722 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
Huh-7	EC₅₀	1.6 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
H9	EC₅₀	1.02 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 2056 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 2056 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
Huh-7	EC₅₀	1.6 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
H9	EC₅₀	3.51 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 2101 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 2101 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
Huh-7	EC₅₀	1.8 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
H9	EC₅₀	1.45 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade C isolate 2914 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade C isolate 2914 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
E6SM	EC₅₀	0.024 2 Compound: PMEA	Antiviral activity against G strain of HSV-2 in E6SM cells. Antiviral activity against G strain of HSV-2 in E6SM cells.	[PMID: 14584956]
Huh-7	EC₅₀	6 3 Compound: PMEA, Adefovir	Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis	[PMID: 21803462]
H9	EC₅₀	2.74 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade C isolate 4110 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade C isolate 4110 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
E6SM	EC₅₀	0.024 2 Compound: PMEA	Antiviral activity against KOS strain of HSV-1 in E6SM cells. Antiviral activity against KOS strain of HSV-1 in E6SM cells.	[PMID: 14584956]
Huh-7	EC₅₀	7.7 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
E6SM	EC₅₀	7 6 Compound: PMEA (adefovir)	Inhibition of Herpes simplex virus-1, KOS strain induced cytopathicity in E6SM cell line Inhibition of Herpes simplex virus-1, KOS strain induced cytopathicity in E6SM cell line	[PMID: 11960502]
H9	EC₅₀	0.19 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade F isolate 2338 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade F isolate 2338 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
L1210	IC₅₀	3 3 Compound: 1, PMEA	Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis	[PMID: 24686012]
H9	EC₅₀	0.22 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade G isolate 3187 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade G isolate 3187 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
E6SM	EC₅₀	7 6 Compound: PMEA (adefovir)	Inhibition of Herpes simplex virus-2 (G strain) induced cytopathicity in E6SM cell line Inhibition of Herpes simplex virus-2 (G strain) induced cytopathicity in E6SM cell line	[PMID: 11960502]
MT4	EC₅₀	22 3 Compound: PMEA	Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells	10.1016/0960-894X(95)00208-B
HEK-293T	CC₅₀	>100 3 Compound: PMEA	Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method	[PMID: 17470654]
E6SM	EC₅₀	7 6 Compound: PMEA (adefovir)	Inhibition of thymidine kinase deficient Herpes simplex virus-1 VMW 1837 strain induced cytopathicity in E6SM cell line Inhibition of thymidine kinase deficient Herpes simplex virus-1 VMW 1837 strain induced cytopathicity in E6SM cell line	[PMID: 11960502]
PBMC	CC₅₀	> 30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay	[PMID: 21803462]
H9	CC₅₀	> 30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay	[PMID: 21803462]
Vero	IC₅₀	119 3 Compound: 1	Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro	[PMID: 8021925]
H9	EC₅₀	0.19 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade F isolate 2338 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade F isolate 2338 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	0.22 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade G isolate 3187 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade G isolate 3187 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
WI-38	CC₅₀	124.7 3 Compound: PMEA	Cytotoxicity against human WI38 cells by neutral red assay Cytotoxicity against human WI38 cells by neutral red assay	[PMID: 18285481]
WI-38	EC₅₀	95.8 3 Compound: PMEA	Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis	[PMID: 18285481]
H9	EC₅₀	0.32 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade A/E isolate 2165 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade A/E isolate 2165 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	0.32 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade D isolate 1649 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade D isolate 1649 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	1.02 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 2056 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 2056 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	1.1 3 Compound: PMEA, Adefovir	Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
H9	EC₅₀	1.45 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade C isolate 2914 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade C isolate 2914 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	1.85 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 1722 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 1722 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	17.76 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade A isolate 4113 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade A isolate 4113 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	2.74 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade C isolate 4110 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade C isolate 4110 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	3.51 3 Compound: PMEA, Adefovir	Antiviral activity against HIV1 clade B isolate 2101 infected in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 clade B isolate 2101 infected in human H9 cells assessed as inhibition of viral replication	[PMID: 21803462]
H9	EC₅₀	7.9 3 Compound: PMEA, Adefovir	Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity	[PMID: 21803462]
HEK-293T	CC₅₀	> 100 3 Compound: PMEA	Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method	[PMID: 17470654]
HEL	EC₅₀	0.035 2 Compound: PMEA	Antiviral activity against 07/1 strain of VZV in HEL (human erythroleukemia) cells. Antiviral activity against 07/1 strain of VZV in HEL (human erythroleukemia) cells.	[PMID: 14584956]
HEL	EC₅₀	0.03 2 Compound: PMEA	Antiviral activity against OKA strain of VZV in HEL (human erythroleukemia) cells. Antiviral activity against OKA strain of VZV in HEL (human erythroleukemia) cells.	[PMID: 14584956]
HEL	EC₅₀	0.1 2 Compound: PMEA	Antiviral activity against AD169 strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells. Antiviral activity against AD169 strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells.	[PMID: 14584956]
HEL	EC₅₀	0.27 2 Compound: PMEA	Antiviral activity against Davis strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells. Antiviral activity against Davis strain of cytomegalovirus (CMV) in HEL (human erythroleukemia) cells.	[PMID: 14584956]
HEL	EC₅₀	10 6 Compound: PMEA (adefovir)	Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) 07/1 strain induced cytopathicity n HEL cell line Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) 07/1 strain induced cytopathicity n HEL cell line	[PMID: 11960502]
HEL	EC₅₀	10 6 Compound: PMEA (adefovir)	Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) YS/R strain induced cytopathicity in HEL cell line Inhibition of Thymidine kinase deficient (TK-) Varicella-Zoster virus (VZV) YS/R strain induced cytopathicity in HEL cell line	[PMID: 11960502]
HEL	EC₅₀	10 6 Compound: PMEA (adefovir)	Inhibition of Varicella-Zoster virus (VZV) OKA strain induced cytopathicity in HEL cell line Inhibition of Varicella-Zoster virus (VZV) OKA strain induced cytopathicity in HEL cell line	[PMID: 11960502]
HEL	EC₅₀	10 6 Compound: PMEA (adefovir)	Inhibition of Varicella-Zoster virus (VZV) YS strain induced cytopathicity in HEL cell line Inhibition of Varicella-Zoster virus (VZV) YS strain induced cytopathicity in HEL cell line	[PMID: 11960502]
HEL	EC₅₀	114.6 3 Compound: 1, PMEA, Adefovir	Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against Human cytomegalovirus Davis infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HEL	EC₅₀	117.6 3 Compound: 1, PMEA, Adefovir	Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against Human cytomegalovirus AD169 infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HEL	EC₅₀	128 6 Compound: PMEA	Antiviral activity against foscarnet-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against foscarnet-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HEL	EC₅₀	137 6 Compound: PMEA	Antiviral activity against acyclovir-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against acyclovir-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HEL	EC₅₀	18 6 Compound: PMEA	Antiviral activity against (S)-3-hydroxy-2-phosphonomethoxypropyl cytosine-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against (S)-3-hydroxy-2-phosphonomethoxypropyl cytosine-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HEL	EC₅₀	20 3 Compound: PMEA, Adefovir	Antiviral activity against Herpes simplex virus type 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against Herpes simplex virus type 2 G infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 21803462]
HEL 299	CC₅₀	211 3 Compound: 3a, PMEA	Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis	[PMID: 17893157]
HEL	EC₅₀	20 3 Compound: PMEA, Adefovir	Antiviral activity against TK-deficient and ACR-resistant Herpes simplex virus type 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against TK-deficient and ACR-resistant Herpes simplex virus type 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 21803462]
HEL 299	EC₅₀	>183 3 Compound: 3a, PMEA	Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
HEL	EC₅₀	20 6 Compound: PMEA	Antiviral activity against HCMV 521 with U97 and DNA polymerase mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against HCMV 521 with U97 and DNA polymerase mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HeLa	CC₅₀	>250 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
HEL	EC₅₀	24.9 3 Compound: 1, PMEA, Adefovir	Antiviral activity against Human herpesvirus 2 G infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against Human herpesvirus 2 G infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HEL	EC₅₀	4.7 3 Compound: 1, PMEA	Antiviral activity against Herpes simplex virus KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Herpes simplex virus KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity	[PMID: 24686012]
HeLa	IC₅₀	181 3 Compound: 1, PMEA	Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
HepG2	CC₅₀	203 3 Compound: adefovir	Cytotoxicity against HepG2.2.15 cells Cytotoxicity against HepG2.2.15 cells	[PMID: 16854087]
HEL	EC₅₀	41.4 3 Compound: 1, PMEA, Adefovir	Antiviral activity against acyclovir-resistant Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against acyclovir-resistant Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HepG2	EC₅₀	2 3 Compound: PMEA	Compound tested for anti-HBV (hepatitis B virus) activity in HepG2 2.2.15 cell line Compound tested for anti-HBV (hepatitis B virus) activity in HepG2 2.2.15 cell line	[PMID: 15139764]
HEL	EC₅₀	42.5 3 Compound: 1, PMEA, Adefovir	Antiviral activity against Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against Human herpesvirus 1 KOS infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HepG2	IC₅₀	42.1 3 Compound: PMEA, 1	Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay	[PMID: 17888662]
HEL	EC₅₀	42 6 Compound: PMEA	Antiviral activity against HCMV 530 with U97 and DNA polymerase mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against HCMV 530 with U97 and DNA polymerase mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HepG2 2.2.15	CC₅₀	57 3 Compound: adefovir	Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay	[PMID: 17499889]
HEL	EC₅₀	5 3 Compound: 1, PMEA, Adefovir	Antiviral activity against VZV 07/1 infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against VZV 07/1 infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HepG2 2.2.15	CC₅₀	540 3 Compound: adefovir	Cytotoxicity against human HepG2(2.2.15) cells Cytotoxicity against human HepG2(2.2.15) cells	[PMID: 20000776]
HEL	EC₅₀	5.8 6 Compound: PMEA	Antiviral activity against ganciclovir-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against ganciclovir-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HepG2 2.2.15	CC₅₀	540 3 Compound: Adefovir	Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay	[PMID: 23353737]
HEL	EC₅₀	6.3 3 Compound: 1, PMEA	Antiviral activity against Herpes simplex virus G infected in HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Herpes simplex virus G infected in HEL cells assessed as inhibition of virus-induced cytopathicity	[PMID: 24686012]
HepG2 2.2.15	CC₅₀	490 3 Compound: Adefovir	Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay	[PMID: 25650312]
HEL	EC₅₀	6.7 3 Compound: 1, PMEA, Adefovir	Antiviral activity against VZV OKA infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against VZV OKA infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HEL	EC₅₀	7 3 Compound: 1, PMEA	Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against thymidine kinase-deficient acyclovir-resistant Herpes simplex virus KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity	[PMID: 24686012]
HepG2 2.2.15	CC₅₀	200 3 Compound: Adefovir	Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay	[PMID: 28082068]
HEL	EC₅₀	89 3 Compound: PMEA, Adefovir	Antiviral activity against Herpes simplex virus type 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against Herpes simplex virus type 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 21803462]
HepG2 2.2.15	EC₅₀	7.8 3 Compound: Adefovir	Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth	[PMID: 21930377]
HEL	EC₅₀	9.1 6 Compound: PMEA	Antiviral activity against (S)-3-hydroxy-2-phosphonomethoxypropyl adenine-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against (S)-3-hydroxy-2-phosphonomethoxypropyl adenine-resistant HCMV with DNA polymerase mutant in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HepG2 2.2.15	EC₅₀	5.5 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
HepG2 2.2.15	EC₅₀	2.1 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb	[PMID: 21930377]
HEL	EC₅₀	90 6 Compound: PMEA	Antiviral activity against HCMV 6 with U97 mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against HCMV 6 with U97 mutation in HEL cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 18707089]
HepG2 2.2.15	EC₅₀	1.9 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
HEL	EC₅₀	> 0.17 2 Compound: PMEA	Antiviral activity against vaccinia virus in HEL (human erythroleukemia) cells. Antiviral activity against vaccinia virus in HEL (human erythroleukemia) cells.	[PMID: 14584956]
HEL	EC₅₀	> 183 3 Compound: 1, PMEA, Adefovir	Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection against virus-induced cytopathicity Antiviral activity against Vaccinia virus infected in HEL cells assessed as protection against virus-induced cytopathicity	[PMID: 21565516]
HepG2 2.2.15	EC₅₀	1.6 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
HepG2 2.2.15	EC₅₀	1.3 3 Compound: Adefovir	Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method	[PMID: 21930377]
HEL	EC₅₀	> 200 3 Compound: PMEA, Adefovir	Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect Antiviral activity against Vaccinia virus infected in HEL cells assessed as inhibition of virus-induced cytopathic effect	[PMID: 21803462]
HepG2 2.2.15	IC₅₀	286 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA	[PMID: 20000776]
HepG2 2.2.15	IC₅₀	286 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA	[PMID: 23353737]
HepG2 2.2.15	IC₅₀	305 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA	[PMID: 20000776]
HepG2 2.2.15	IC₅₀	305 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA	[PMID: 23353737]
HEL 299	CC₅₀	211 3 Compound: 3a, PMEA	Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis	[PMID: 17893157]
HepG2 2.2.15	IC₅₀	0.517 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR	[PMID: 20000776]
HEL 299	EC₅₀	> 183 3 Compound: 3a, PMEA	Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
HepG2 2.2.15	IC₅₀	0.517 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method	[PMID: 23353737]
HEL 299	EC₅₀	> 183 3 Compound: 3a, PMEA	Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining	[PMID: 17893157]
HepG2 2.2.15	IC₅₀	215 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA	[PMID: 25650312]
HeLa	CC₅₀	> 250 3 Compound: 1, PMEA, Adefovir	Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis	[PMID: 21565516]
HepG2 2.2.15	IC₅₀	257 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA	[PMID: 25650312]
HeLa	IC₅₀	181 3 Compound: 1, PMEA	Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis	[PMID: 24686012]
Huh-7	CC₅₀	>150 3 Compound: PMEA, Adefovir	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 21803462]
HepG2	CC₅₀	203 3 Compound: adefovir	Cytotoxicity against HepG2.2.15 cells Cytotoxicity against HepG2.2.15 cells	[PMID: 16854087]
Huh-7	EC₅₀	7.7 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Huh-7	EC₅₀	1.6 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
HepG2	EC₅₀	2 3 Compound: PMEA	Compound tested for anti-HBV (hepatitis B virus) activity in HepG2 2.2.15 cell line Compound tested for anti-HBV (hepatitis B virus) activity in HepG2 2.2.15 cell line	[PMID: 15139764]
Huh-7	EC₅₀	1.8 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
HepG2	IC₅₀	42.1 3 Compound: PMEA, 1	Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay	[PMID: 17888662]
Huh-7	EC₅₀	1.5 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Huh-7	EC₅₀	1.3 3 Compound: adefovir	Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Huh-7	EC₅₀	6 3 Compound: PMEA, Adefovir	Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis	[PMID: 21803462]
L1210	IC₅₀	3 3 Compound: 1, PMEA	Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis	[PMID: 24686012]
HepG2 2.2.15	CC₅₀	200 3 Compound: Adefovir	Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay	[PMID: 28082068]
HepG2 2.2.15	CC₅₀	490 3 Compound: Adefovir	Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay	[PMID: 25650312]
HepG2 2.2.15	CC₅₀	540 3 Compound: Adefovir	Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay	[PMID: 23353737]
HepG2 2.2.15	CC₅₀	540 3 Compound: adefovir	Cytotoxicity against human HepG2(2.2.15) cells Cytotoxicity against human HepG2(2.2.15) cells	[PMID: 20000776]
HepG2 2.2.15	CC₅₀	57 3 Compound: adefovir	Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay	[PMID: 17499889]
MT4	CC₅₀	187 3 Compound: PMEA	Compound was evaluated for the concentration required to reduce the viability of MT-4 cells. Compound was evaluated for the concentration required to reduce the viability of MT-4 cells.	10.1016/0960-894X(95)00585-H
MT4	CC₅₀	>10 3 Compound: 1	Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1. Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1.	[PMID: 8960556]
MT4	CC₅₀	187 3 Compound: PMEA	Cytotoxic concentration required to reduce the viability of MT-4 cells Cytotoxic concentration required to reduce the viability of MT-4 cells	10.1016/0960-894X(95)00208-B
MT4	CC₅₀	144 3 Compound: 2	In vitro cytotoxic concentration against MT-4 cells In vitro cytotoxic concentration against MT-4 cells	[PMID: 11327587]
MT4	EC₅₀	20 3 Compound: PMEA	Compound was evaluated for the inhibition of HIV-1 induced cytopathic effect in MT-4 cells. Compound was evaluated for the inhibition of HIV-1 induced cytopathic effect in MT-4 cells.	10.1016/0960-894X(95)00585-H
HepG2 2.2.15	EC₅₀	1.3 3 Compound: Adefovir	Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method	[PMID: 21930377]
HepG2 2.2.15	EC₅₀	1.6 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
MT4	EC₅₀	>10 3 Compound: 1	Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1. Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1.	[PMID: 8960556]
HepG2 2.2.15	EC₅₀	1.9 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
MT4	EC₅₀	22 3 Compound: PMEA	Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells	10.1016/0960-894X(95)00208-B
MT4	EC₅₀	7 3 Compound: 2	In vitro antiviral activity against HIV-1 in MT-4 cells In vitro antiviral activity against HIV-1 in MT-4 cells	[PMID: 11327587]
HepG2 2.2.15	EC₅₀	2.1 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb	[PMID: 21930377]
HepG2 2.2.15	EC₅₀	5.5 3 Compound: Adefovir	Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me	[PMID: 21930377]
MT4	EC₅₀	7.5 3 Compound: 2	In vitro antiviral activity against HIV-2 in MT-4 cells In vitro antiviral activity against HIV-2 in MT-4 cells	[PMID: 11327587]
HepG2 2.2.15	EC₅₀	7.8 3 Compound: Adefovir	Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth	[PMID: 21930377]
MT4	IC₅₀	274 6 Compound: 4	Cellular toxic effect was determined in MT-4 cells Cellular toxic effect was determined in MT-4 cells	[PMID: 11606136]
HepG2 2.2.15	IC₅₀	0.517 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method	[PMID: 23353737]
MT4	IC₅₀	2 3 Compound: PMEA	Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells	10.1016/S0960-894X(01)80206-7
HepG2 2.2.15	IC₅₀	0.517 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR	[PMID: 20000776]
MT4	IC₅₀	6.5 3 Compound: PMEA	Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells	10.1016/S0960-894X(01)80206-7
HepG2 2.2.15	IC₅₀	215 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA	[PMID: 25650312]
MT4	IC₅₀	4.1 6 Compound: 4	Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells	[PMID: 11606136]
MT4	IC₅₀	3.8 6 Compound: 4	Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells	[PMID: 11606136]
HepG2 2.2.15	IC₅₀	257 3 Compound: Adefovir	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA	[PMID: 25650312]
HepG2 2.2.15	IC₅₀	286 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA	[PMID: 23353737]
PBMC	CC₅₀	>30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay	[PMID: 21803462]
Vero	CC₅₀	>100 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-1. Compound was tested for antiviral activity against the Vero cells infected with HSV-1.	[PMID: 8960556]
HepG2 2.2.15	IC₅₀	286 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA	[PMID: 20000776]
Vero	CC₅₀	>= 250 3 Compound: PMEA	The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures	10.1016/0960-894X(95)00208-B
HepG2 2.2.15	IC₅₀	305 3 Compound: Adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA	[PMID: 23353737]
Vero	EC₅₀	58 3 Compound: PMEA	Anti-herpes virus activity was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells Anti-herpes virus activity was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells	10.1016/0960-894X(95)00208-B
HepG2 2.2.15	IC₅₀	305 3 Compound: adefovir	Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA	[PMID: 20000776]
Huh-7	CC₅₀	> 150 3 Compound: PMEA, Adefovir	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 21803462]
Vero	EC₅₀	69 3 Compound: PMEA	Anti-herpes virus activity was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells Anti-herpes virus activity was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells	10.1016/0960-894X(95)00208-B
Vero	EC₅₀	38.5 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-1. Compound was tested for antiviral activity against the Vero cells infected with HSV-1.	[PMID: 8960556]
Huh-7	EC₅₀	1.3 3 Compound: adefovir	Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Vero	EC₅₀	32.7 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-2 Compound was tested for antiviral activity against the Vero cells infected with HSV-2	[PMID: 8960556]
Huh-7	EC₅₀	1.5 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Huh-7	EC₅₀	1.6 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Vero	IC₅₀	119 3 Compound: 1	Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro	[PMID: 8021925]
WI-38	CC₅₀	124.7 3 Compound: PMEA	Cytotoxicity against human WI38 cells by neutral red assay Cytotoxicity against human WI38 cells by neutral red assay	[PMID: 18285481]
Huh-7	EC₅₀	1.6 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
Huh-7	EC₅₀	1.8 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
WI-38	EC₅₀	95.8 3 Compound: PMEA	Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis	[PMID: 18285481]
Huh-7	EC₅₀	6 3 Compound: PMEA, Adefovir	Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis	[PMID: 21803462]
Huh-7	EC₅₀	7.7 3 Compound: adefovir	Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay	[PMID: 19072694]
L1210	IC₅₀	3 3 Compound: 1, PMEA	Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis	[PMID: 24686012]
MRC5	CC₅₀	> 100 3 Compound: 1	Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-1. Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-1.	[PMID: 8960556]
MRC5	CC₅₀	> 250 3 Compound: PMEA	The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures The lowest concentration of compound producing overt cytotoxicity in virus-free MRC-5 cell cultures	10.1016/0960-894X(95)00208-B
MRC5	EC₅₀	29.7 3 Compound: 1	Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-1. Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-1.	[PMID: 8960556]
MRC5	EC₅₀	33.5 3 Compound: 1	Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-2. Compound was tested for antiviral activity against the MRC-5 cells infected with HSV-2.	[PMID: 8960556]
MRC5	EC₅₀	36 3 Compound: PMEA	Anti-herpes virus activity was evaluated against human cytomegalovirus (HCMV, strain AD-169) grown in MRC-5 cells Anti-herpes virus activity was evaluated against human cytomegalovirus (HCMV, strain AD-169) grown in MRC-5 cells	10.1016/0960-894X(95)00208-B
MT2	EC₅₀	1.1 3 Compound: 1, PMEA, Adefovir	Antiviral activity against HIV 1 LAI infected in MT2 cells Antiviral activity against HIV 1 LAI infected in MT2 cells	[PMID: 21565516]
MT4	CC₅₀	144 3 Compound: 2	In vitro cytotoxic concentration against MT-4 cells In vitro cytotoxic concentration against MT-4 cells	[PMID: 11327587]
MT4	CC₅₀	187 3 Compound: PMEA	Cytotoxic concentration required to reduce the viability of MT-4 cells Cytotoxic concentration required to reduce the viability of MT-4 cells	10.1016/0960-894X(95)00208-B
MT4	CC₅₀	187 3 Compound: PMEA	Compound was evaluated for the concentration required to reduce the viability of MT-4 cells. Compound was evaluated for the concentration required to reduce the viability of MT-4 cells.	10.1016/0960-894X(95)00585-H
MT4	CC₅₀	> 10 3 Compound: 1	Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1. Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1.	[PMID: 8960556]
MT4	EC₅₀	20 3 Compound: PMEA	Compound was evaluated for the inhibition of HIV-1 induced cytopathic effect in MT-4 cells. Compound was evaluated for the inhibition of HIV-1 induced cytopathic effect in MT-4 cells.	10.1016/0960-894X(95)00585-H
MT4	EC₅₀	22 3 Compound: PMEA	Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells	10.1016/0960-894X(95)00208-B
MT4	EC₅₀	7 3 Compound: 2	In vitro antiviral activity against HIV-1 in MT-4 cells In vitro antiviral activity against HIV-1 in MT-4 cells	[PMID: 11327587]
MT4	EC₅₀	7.5 3 Compound: 2	In vitro antiviral activity against HIV-2 in MT-4 cells In vitro antiviral activity against HIV-2 in MT-4 cells	[PMID: 11327587]
MT4	EC₅₀	> 10 3 Compound: 1	Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1. Compound was tested for antiviral activity against the MT-4 cell lines infected with HIV-1.	[PMID: 8960556]
MT4	IC₅₀	2 3 Compound: PMEA	Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells	10.1016/S0960-894X(01)80206-7
MT4	IC₅₀	274 6 Compound: 4	Cellular toxic effect was determined in MT-4 cells Cellular toxic effect was determined in MT-4 cells	[PMID: 11606136]
MT4	IC₅₀	3.8 6 Compound: 4	Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells Inhibition of cytopathogenicity against human HIV-2(LAV-2) in MT-4 cells	[PMID: 11606136]
MT4	IC₅₀	4.1 6 Compound: 4	Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells Inhibition of cytopathogenicity against human HIV-1(IIIB) in MT-4 cells	[PMID: 11606136]
MT4	IC₅₀	6.5 3 Compound: PMEA	Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells Compound was evaluated for its ability to Inhibit HIV replication in MT-4 cells	10.1016/S0960-894X(01)80206-7
PBMC	CC₅₀	> 30 3 Compound: PMEA, Adefovir	Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay	[PMID: 21803462]
Vero	CC₅₀	> 100 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-1. Compound was tested for antiviral activity against the Vero cells infected with HSV-1.	[PMID: 8960556]
Vero	CC₅₀	>= 250 3 Compound: PMEA	The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures The lowest concentration of compound producing overt cytotoxicity in virus-free vero cell cultures	10.1016/0960-894X(95)00208-B
Vero	EC₅₀	32.7 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-2 Compound was tested for antiviral activity against the Vero cells infected with HSV-2	[PMID: 8960556]
Vero	EC₅₀	38.5 3 Compound: 1	Compound was tested for antiviral activity against the Vero cells infected with HSV-1. Compound was tested for antiviral activity against the Vero cells infected with HSV-1.	[PMID: 8960556]
Vero	EC₅₀	58 3 Compound: PMEA	Anti-herpes virus activity was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells Anti-herpes virus activity was evaluated against Herpes simplex virus type 1 (HSV-1,strain HF) grown in Vero cells	10.1016/0960-894X(95)00208-B
Vero	EC₅₀	69 3 Compound: PMEA	Anti-herpes virus activity was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells Anti-herpes virus activity was evaluated against Herpes simplex virus type 2 (HSV-2,strain G) grown in Vero cells	10.1016/0960-894X(95)00208-B
Vero	IC₅₀	119 3 Compound: 1	Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro	[PMID: 8021925]
WI-38	CC₅₀	124.7 3 Compound: PMEA	Cytotoxicity against human WI38 cells by neutral red assay Cytotoxicity against human WI38 cells by neutral red assay	[PMID: 18285481]
WI-38	EC₅₀	95.8 3 Compound: PMEA	Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis	[PMID: 18285481]

体外実験

Studies to elucidate the mechanism of action of Adefovir against herpesvirus replication reveals that the phosphorylation of Adefovir occurred intracellularly and is carried out by host cellular enzymes. The diphosphorylated derivatives of Adefovir targeted the viral DNA polymerase and also acted as DNA chain terminators. Adenylate kinase is shown to be responsible for the first phosphorylation, which was followed by ADP kinase and creatine kinase, forming Adefovir diphosphate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Unaffected by food, Adefovir achieves 60% oral bioavailability. Its half-life is 12-30 hours and Adefovir undergoes renal excretion without significant metabolites. Adefovir does not substantially affect the cytochrome P450 system^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

273.19

分子式

C₈H₁₂N₅O₄P

CAS 番号

106941-25-7

Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

0.1 M NaOH : 10 mg/mL (36.60 mM; ultrasonic and adjust pH to 10 with NaOH)

H₂O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6605 mL	18.3023 mL	36.6046 mL
5 mM	0.7321 mL	3.6605 mL	7.3209 mL
10 mM	0.3660 mL	1.8302 mL	3.6605 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.74%

Select Batch:

データシート (273 KB) SDS (479 KB)

COA (246 KB) HNMR (117 KB) RP-HPLC (191 KB)

取扱説明書 (2659 KB)

参考文献

[1]. X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.

[2]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16. [Content Brief]

[3]. Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

0.1 M NaOH	1 mM	3.6605 mL	18.3023 mL	36.6046 mL	91.5114 mL
	5 mM	0.7321 mL	3.6605 mL	7.3209 mL	18.3023 mL
	10 mM	0.3660 mL	1.8302 mL	3.6605 mL	9.1511 mL
	15 mM	0.2440 mL	1.2202 mL	2.4403 mL	6.1008 mL
	20 mM	0.1830 mL	0.9151 mL	1.8302 mL	4.5756 mL
	25 mM	0.1464 mL	0.7321 mL	1.4642 mL	3.6605 mL
	30 mM	0.1220 mL	0.6101 mL	1.2202 mL	3.0504 mL

Adefovir Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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アデフォビル (Synonyms: Adefovir)

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アデフォビル (Synonyms: Adefovir)

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アデフォビル 関連抗体

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おすすめ

•関連スクリーニングライブラリ:

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•関連タンパク質:

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アデフォビル 関連抗体

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Complete Stock Solution Preparation Table

Adefovir Related Classifications

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The molarity calculator equation

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アデフォビル関連抗体

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