106941-25-7
106941-25-7
Chemical Structure
Adefovir
Synonym(s): GS-0393; PMEA
- CAS No.: 106941-25-7
- Formula:C8H12N5O4P
- Molecular Weight:273.19
IUPAC Name: ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
InChIKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N
SMILES: NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1
Biological Activity: Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Adefovir | 99.82% | Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses. | ||||||||||||||||||||
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Adefovir-d4 | 98.69% | Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses. | ||||||||||||||||||||
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PMEDAP (Standard) | ≥98% | PMEDAP (Standard) is the analytical standard of PMEDAP (HY-106382). This product is intended for research and analytical applications. PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality. | ||||||||||||||||||||
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Tenofovir | 99.92% | Tenofovir (GS 1278; PMPA) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV). | ||||||||||||||||||||
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Tenofovir hydrate (Standard) | 99.88% | Tenofovir hydrate (Standard) (GS 1278 hydrate (Standard); PMPA hydrate (Standard)) is the analytical standard of Tenofovir hydrate (HY-13910A). This product is intended for research and analytical applications. Tenofovir hydrate (GS 1278 hydrate; PMPA hydrate) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV). | ||||||||||||||||||||
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(2RS)-FPMPA | (2RS)-FPMPA can be used for synthesis of antiretroviral agents against HIV-1 and HIV-2. | |||||||||||||||||||||
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Adefovir diphosphate | Adefovir diphosphate is an antiviral compound with activity against hepatitis B virus (HBV). Adefovir diphosphate blocks the replication of HBV by inhibiting reverse transcriptase. Adefovir diphosphate has also shown activity against other viruses such as herpes viruses and human immunodeficiency virus. Adefovir diphosphate is used as an effective inhibitory option in the suppression of chronic hepatitis B. The mechanism of action of Adefovir diphosphate involves blocking the autophosphorylation of growth factor receptors, thereby potentially reducing the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B. | |||||||||||||||||||||
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PMEG | PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma. | |||||||||||||||||||||
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(S)-Tenofovir (Standard) | ≥98% | (S)-Tenofovir (Standard) is the analytical standard of (S)-Tenofovir. This product is intended for research and analytical applications. (S)-Tenofovir is the less active S-enantiomer of Tenofovir (HY-13910). Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV). (S)-Tenofovir has low activity to Orf virus. (S)-Tenofovir can be used for research on contagious pustular dermatitis. | ||||||||||||||||||||
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(S)-HPMPA | 99.89% | (S)-HPMPA is an antiviral agent. (S)-HPMPA can bind to and interfere with viral DNA polymerase activity, thereby inhibiting viral DNA synthesis. (S)-HPMPA can be used for the study of DNA viruses. | ||||||||||||||||||||
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Tenofovir impurity 11 | Tenofovir impurity 11 (Isopropyl tenofovir) is an impurity of Tenofovir. | |||||||||||||||||||||
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Tenofovir impurity 10 | Tenofovir impurity 10 is an impurity of Tenofovir. | |||||||||||||||||||||
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References
- [1]. X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327.
- [2]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16. [Content Brief]
- [3]. Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.
