1. Anti-infection
  2. HBV
    Reverse Transcriptase
  3. Adefovir

Adefovir (Synonyms: GS-0393; PMEA)

Cat. No.: HY-B1826 Purity: >98.0%
Handling Instructions

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

For research use only. We do not sell to patients.

Adefovir Chemical Structure

Adefovir Chemical Structure

CAS No. : 106941-25-7

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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25 mg USD 90 In-stock
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50 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

IC50 & Target

HBV[1][2][3];
DNA polymerase[1][2]

In Vitro

Studies to elucidate the mechanism of action of Adefovir against herpesvirus replication reveals that the phosphorylation of Adefovir occurred intracellularly and is carried out by host cellular enzymes. The diphosphorylated derivatives of Adefovir targeted the viral DNA polymerase and also acted as DNA chain terminators. Adenylate kinase is shown to be responsible for the first phosphorylation, which was followed by ADP kinase and creatine kinase, forming Adefovir diphosphate[1].

In Vivo

Unaffected by food, Adefovir achieves 60% oral bioavailability. Its half-life is 12-30 hours and Adefovir undergoes renal excretion without significant metabolites. Adefovir does not substantially affect the cytochrome P450 system[3].

Molecular Weight

273.19

Formula

C₈H₁₂N₅O₄P

CAS No.

106941-25-7

SMILES

NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

AdefovirGS-0393PMEAGS0393GS 0393HBVReverse TranscriptaseHepatitis B virusreversetranscriptaseantiviraldiphosphateadenosinemonophosphateHIVherpesvirusesInhibitorinhibitorinhibit

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Adefovir
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