Anti-BK virus activity of nucleoside analogs

  • Antimicrob Agents Chemother. 2008 Apr;52(4):1519-21. doi: 10.1128/AAC.01241-07.
Parmjeet Randhawa  1 ,  Jiri Zemlicka ,  Andreas Sauerbrei ,  Chris Meier ,  Karl Y Hostetler ,  James R Beadle ,  Noush Afarin Farasati ,  Yuchen Huang ,  Matthews Bradley
Affiliations
  • 1. Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA. [email protected]
PMID: 18285481 DOI: 10.1128/AAC.01241-07
Abstract

Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.