1. Anti-infection
  2. HBV
    Reverse Transcriptase
  3. Adefovir dipivoxil

Adefovir dipivoxil (Synonyms: GS 0840)

Cat. No.: HY-B0255 Purity: 99.87%
Handling Instructions

Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

For research use only. We do not sell to patients.

Adefovir dipivoxil Chemical Structure

Adefovir dipivoxil Chemical Structure

CAS No. : 142340-99-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target: NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].

Clinical Trial
Molecular Weight

501.47

Formula

C₂₀H₃₂N₅O₈P

CAS No.

142340-99-6

SMILES

NC1=C2N=CN(CCOCP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (199.41 mM)

H2O : 0.67 mg/mL (1.34 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9941 mL 9.9707 mL 19.9414 mL
5 mM 0.3988 mL 1.9941 mL 3.9883 mL
10 mM 0.1994 mL 0.9971 mL 1.9941 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Adefovir dipivoxilGS 0840GS0840GS-0840HBVReverse TranscriptaseHepatitis B virusInhibitorinhibitorinhibit

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Adefovir dipivoxil
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