2. Anti-infection
  3. SARS-CoV
  4. Adintrevimab

Adintrevimab  (Synonyms: ADG 20)

製品番号: HY-P99423 純度: 96.94%
COA Technical Support

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号 : 2516243-54-0

容量 価格（税別） 在庫状況 数量
1 mg $300 在庫あり
5 mg $780 在庫あり
10 mg $1250 在庫あり
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100 mg   お問い合わせ  

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Adintrevimab 関連抗体

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製品説明

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity

Virus
IC50 & Target

Severe acute respiratory syndrome coronavirus 2
体外実験

The crystallizable fragment (Fc) region of Adintrevimab has a modification to extend its half-life. Adintrevimab binds to a distinct epitope in the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 that partially overlaps the angiotensin-converting enzyme 2 binding site and is highly conserved among sarbecoviruses. In vitro, Adintrevimab has demonstrated potent neutralizing activity against most variants and sublineages of SARS-CoV-2 (including Alpha, Beta, Gamma, and Delta) as well as other SARS-like viruses. Adintrevimab displays reduced in vitro activity against Omicron BA.1/BA.1.1 and lacks activity against BA.2, BA.3, BA.4, and BA.5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adintrevimab 関連抗体
体内実験

Adintrevimab (9.25, 55, 333, or 2,000 μg; i.p.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner[1].
Adintrevimab (5-25 mg/kg; i.v.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg)
Administration: Intraperitoneal injection; single dose
Result: Showed significant reduction in lung viral load and virus-induced lung pathology.
Animal Model: Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 5 mg/kg, 25 mg/kg
Administration: Intravenous injection; single dose
Result: Reduced pulmonary inflammation.
臨床実験
Gene ID
Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.04 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Adintrevimab]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
純度とドキュメンテーション
参考文献
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Adintrevimab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adintrevimab2516243-54-0ADG 20ADG20ADG-20SARS-CoVSARS coronavirusSARS-CoV-2human IgG1 monoclonalInhibitorinhibitorinhibit

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製品名:
Adintrevimab
製品番号:
HY-P99423
数量:
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