AMPA receptor modulator-4 

AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice^[1].

AMPA receptor modulator-4 (compound 15e) has pEC₅₀ of 5.66 on the calcium influx induced by 1 mM Glutamate on HEK293 cells stably expressing the GluA2(Q) subunit^[1].
AMPA receptor modulator-4 has EC_2x=2.1 μM (FlipR)-1.5 μM (FDSS) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMPA receptor modulator-4 (compound 15e; 10 and 30 mg/kg; IP; once) increases the duration of the LTP at a dose of 10 mg/kg in rats^[1].
AMPA receptor modulator-4 (1 and 3 mg/kg; po) 1 h before the three sessions significantly increases the cognition performance of CD1 mice^[1].
AMPA receptor modulator-4 (0.03, 0.1 and 0.3 mg/kg; ip) improves the performance of spontaneous alternation and improves working memory performance in C57BI/6 mice^[1].
AMPA receptor modulator-4 (30, 100 mg/kg; po; once) has non-pro-convulsant effect in NMRI mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

290.74

C₁₁H₁₂ClFN₂O₂S

2917551-59-6

O=S1(C2=CC(Cl)=CC=C2N(C3CC3)CN1CF)=O

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• [1]. Eric Goffin, et al. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. Eur J Med Chem. 2023 Mar 15;250:115221.  [Content Brief]