2917551-59-6
Chemical Structure
AMPA receptor modulator-4
- CAS No.: 2917551-59-6
- Formula:C11H12ClFN2O2S
- Molecular Weight:290.74
IUPAC Name: 7-chloro-4-cyclopropyl-2-(fluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
InChIKey: BFEBOKZKRJKNTQ-UHFFFAOYSA-N
SMILES: O=S1(C2=CC(Cl)=CC=C2N(C3CC3)CN1CF)=O
Biological Activity: AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice[1].
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AMPA receptor modulator-4 | AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice. | |||||||||||||||||||||
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- [1]. Eric Goffin, et al. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. Eur J Med Chem. 2023 Mar 15;250:115221. [Content Brief]
Keywords
